Trace elements and oxidative stress status in patients with psoriasis

Adnan Kirmit; Saadet Kader; Mustafa Aksoy; Ceylan Bal; Cemil Nural; Oruç Aslan

doi:10.5114/ada.2020.94265

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

Trace elements and oxidative stress status in patients with psoriasis

Adnan Kirmit

¹

,

Saadet Kader

²

,

Mustafa Aksoy

³

,

Ceylan Bal

⁴

,

Cemil Nural

⁴

,

Oruç Aslan

¹

Department of Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Turkey
Department of Biochemistry, Karapinar State Hospital, Konya, Turkey
Department of Dermatology, Faculty of Medicine, Harran University, Sanliurfa, Turkey
Department of Biochemistry, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey

Adv Dermatol Allergol 2020; XXXVII (3): 333–339

DOI: https://doi.org/10.5114/ada.2020.94265

Online publish date: 2020/04/07

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Introduction
Psoriasis is a common, inflammatory skin disease of which etiopathogenesis is still not explained clearly, however in which trace elements and oxidative stress are considered to play a role.

Aim
To evaluate the serum trace element and oxidative stress levels in patients diagnosed with psoriasis.

Material and methods
A total of 87 psoriasis patients and 60 healthy subjects were included in the study. Serum sodium (Na), potassium (K), calcium (Ca), phosphorus (P), magnesium (Mg), iron (Fe), selenium (Se), zinc (Zn), copper (Cu) levels, oxidative stress parameters, ischemia-modified albumin (IMA), catalase (CAT), myeloperoxidase (MPO) and ferroxidase (FOX) activity and an inflammatory marker, C-reactive protein (CRP), were examined in all participants.

Results
IMA, IMA/Albumin (IMA/Alb), CAT, Cu, FOX and CRP levels were found to be significantly higher; Se, Zn and albumin levels were significantly lower in the patient group as compared to the control group. No significant difference was found between groups with regard to Na, K, Ca, P, Mg, Fe and MPO levels.

Conclusions
Some trace element levels and oxidant–antioxidant balance were changed in psoriasis patients.

keywords:

Trace elements and oxidative stress status in patients with psoriasis

Adnan Kirmit 1 , Saadet Kader 2 , Mustafa Aksoy 3 , Ceylan Bal 4 , Cemil Nural 4 , Oruç Aslan 1

trace element, selenium, zinc, copper, psoriasis, ischemia-modified albumin

Adnan Kirmit

¹

,

Saadet Kader

²

,

Mustafa Aksoy

³

,

Ceylan Bal

⁴

,

Cemil Nural

⁴

,

Oruç Aslan

¹