Treatment of bisphosphonate-related osteonecrosis of the jaws – a report of seven cases

Joanna Jakiel; Mansur Rahnama; Joanna Szczerba-Gwóźdź

doi:10.5114/wo.2016.65610

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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6/2016
vol. 20

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abstract:

Original paper

Treatment of bisphosphonate-related osteonecrosis of the jaws – a report of seven cases

Joanna Jakiel

,

Mansur Rahnama

,

Joanna Szczerba-Gwóźdź

Contemp Oncol (Pozn) 2016; 20 (6):486–490

DOI: https://doi.org/10.5114/wo.2016.65610

Online publish date: 2017/01/30

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Aim of the study: The aim of the study was to report on seven cases of BRONJ treated with surgical debridement, oral antibiotics and gentamicin-collagen sponge (Collatamp EG) placed in the bone wound.

Material and methods: Seven patients with 9 sites of BRONJ stage 2 were included in the study. Perioperative oral antibiotics, surgical debridement and/or sequestrotomy and gentamicin-collagen sponge (Collatamp EG) were used. Postoperative monitoring was carried out for the next 3 months.

Results: Three weeks after the surgery, six sites of BRONJ in five patients were treated successfully. In two patients on three sites BRONJ stage 1 was observed. Three months after surgery another two sites healed fully. In one patient there was still BRONJ stage 1, however, the area of exposed bone was visibly reduced.

Conclusions: The use of surgical debridement together with oral antibiotic therapy and collagen-gentamycin sponge indicates positive results regarding the surgical treatment of BRONJ.

keywords:

Treatment of bisphosphonate-related osteonecrosis of the jaws – a report of seven cases

Joanna Jakiel , Mansur Rahnama , Joanna Szczerba-Gwóźdź

chemotherapy, infection in oncology, rehabilitation

Joanna Jakiel

,

Mansur Rahnama

,

Joanna Szczerba-Gwóźdź