Treatment of hypertriglyceridemia-induced acute pancreatitis with insulin

Ali Coskun; Nazif Erkan; Savas Yakan; Mehmet Yildirim; Erdem Carti; Deniz Ucar; Erkan Oymaci

doi:10.5114/pg.2014.45412

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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1/2015
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abstract:

Original paper

Treatment of hypertriglyceridemia-induced acute pancreatitis with insulin

Ali Coskun

,

Nazif Erkan

,

Savas Yakan

,

Mehmet Yildirim

,

Erdem Carti

,

Deniz Ucar

,

Erkan Oymaci

Prz Gastroenterol 2015; 10 (1): 18–22

DOI: https://doi.org/10.5114/pg.2014.45412

Online publish date: 2015/01/14

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Introduction: Hypertriglyceridaemia (HT)-induced pancreatitis rarely occurs unless triglyceride levels exceed 1000 mg/dl. Hypertriglyceridaemia over 1,000 mg/dl can provoke acute pancreatitis (AP) and its persistence can worsen the clinical outcome. In contrast, a rapid decrease in triglyceride level is beneficial. Insulin-stimulated lipoprotein lipase is known to decrease serum triglyceride levels. However, their efficacy in HT-induced AP is not well documented.

Aim: To present 12 cases of AP successfully treated by insulin administration.

Material and methods: Three hundred and forty-three cases of AP were diagnosed at our clinic between 2005 and 2012. Twelve (3.5%) of these cases were HT-induced AP. Twelve patients who suffered HT-induced AP are reported. Initial blood triglyceride levels were above 1000 mg/dl. Besides the usual treatment of AP, insulin was administered intravenously in continuous infusion. The patients’ medical records were retrospectively evaluated in this study.

Results: Serum triglyceride levels decreased to < 500 mg/dl within 2–3 days. No complications of treatment were seen and good clinical outcome was observed.

Conclusions: Our results are compatible with the literature. Insulin may be used safely and effectively in HT-induced AP therapy. Administration of insulin is efficient when used to reduce triglyceride levels in patients with HT-induced

keywords:

Treatment of hypertriglyceridemia-induced acute pancreatitis with insulin

Ali Coskun , Nazif Erkan , Savas Yakan , Mehmet Yildirim , Erdem Carti , Deniz Ucar , Erkan Oymaci

acute pancreatitis, hypertriglyceridemia, hyperlipidaemia, insulin

Ali Coskun

,

Nazif Erkan

,

Savas Yakan

,

Mehmet Yildirim

,

Erdem Carti

,

Deniz Ucar

,

Erkan Oymaci