Treatment of stage I seminoma: 25 years of experience

Małgorzata Pilichowska; Piotr Pęczkowski; Dorota Rosińska-Okrasa; Barbara Trzaska; Anna Skowrońska-Gardas; Tomasz Demkow

doi:10.5114/wo.2012.28788

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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2/2012
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abstract:

Original paper

Treatment of stage I seminoma: 25 years of experience

Małgorzata Pilichowska

,

Piotr Pęczkowski

,

Dorota Rosińska-Okrasa

,

Barbara Trzaska

,

Anna Skowrońska-Gardas

,

Tomasz Demkow

Wspolczesna Onkol 2012; 16 (2): 104–107

DOI: https://doi.org/10.5114/wo.2012.28788

Online publish date: 2012/05/29

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Aim of the study: To review management and outcomes in patients with stage I seminoma after orchidectomy.

Material and methods: Between 1979 and 2004 a total 292 patients with stage I seminoma were treated with adjuvant chemotherapy or radiotherapy or were placed on surveillance. Median age at diagnosis was 36 years (range 20-69), with median follow-up 76.5 months (range 11-294). Of the patients, 200 (68.5%) were treated with adjuvant chemotherapy, 72 (24.6%) were irradiated and 20 (6.8%) were placed on surveillance.

Results: The probability of 5-year overall survival and relapse-free survival for the entire group was 100% and 95.1% respectively. The 5-year relapse-free survival for adjuvant chemotherapy was 97.2%, for radiotherapy 94.6%, and 31.4% for

the surveillance group. Of 24 (8.4%) patients who had relapse in lymph nodes and/or internal organs, 14/20 patients were in the surveillance group. All patients who had a relapse were salvaged successfully with chemotherapy. The toxicity of chemotherapy and radiotherapy was acceptable. No severe reactions were observed.

Conclusion: Our results confirm the excellent prognosis for patients with stage I seminoma after orchidectomy treated with adjuvant chemotherapy or radiotherapy. The high rate of relapse in our surveillance group suggests the necessity of adjuvant treatment.

keywords:

Treatment of stage I seminoma: 25 years of experience

Małgorzata Pilichowska , Piotr Pęczkowski , Dorota Rosińska-Okrasa , Barbara Trzaska , Anna Skowrońska-Gardas , Tomasz Demkow

seminoma stage I, radiotherapy, chemotherapy, surveillance

Małgorzata Pilichowska

,

Piotr Pęczkowski

,

Dorota Rosińska-Okrasa

,

Barbara Trzaska

,

Anna Skowrońska-Gardas

,

Tomasz Demkow