Two in one: simultaneous use of two long-acting antipsychotics in schizophrenia

Marek Jarema

eISSN: 2449-9315
ISSN: 1234-8279

Pharmacotherapy in Psychiatry and Neurology/Farmakoterapia w Psychiatrii i Neurologii

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1/2021
vol. 37

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abstract:

Review paper

Two in one: simultaneous use of two long-acting antipsychotics in schizophrenia

Marek Jarema

¹

3rd Department of Psychiatry, Institute of Psychiatry and Neurology in Warsaw, Poland

Farmakoterapia w Psychiatrii i Neurologii 2021, 37 (1), 45–51

Online publish date: 2021/11/17

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Objectives
This paper aims to review the literature regarding the possible simultaneous use of two long-acting antipsychotics in the treatment of schizophrenia.

Selected literature review
Despite using the appropriate dose in antipsychotic treatment and continuing it for the necessary period, it happens that such treatment may be considered ineffective. In such a case, to supplement the clinical effect of antipsychotics, the addition of a second antipsychotic medication, mood stabiliser, or an antidepressant may be considered. If the inadequate response to the treatment results from poor medication adherence, the use of long-acting antipsychotic is recommended. Some clinicians, however, try to use two long-acting antipsychotics simultaneously.

Conclusions
Sparse available data did not allow us to conclude that the simultaneous use of two long-acting antipsychotic agents significantly improves the outcome of pharmacological treatment of schizophrenia.

keywords:

Two in one: simultaneous use of two long-acting antipsychotics in schizophrenia

Marek Jarema 1

schizophrenia, pharmacological treatment, long-acting antipsychotics

Marek Jarema

¹