Ugryzienia przez pluskwy domowe imitujące pemfigoid pęcherzowy – opis dwóch przypadków

Introduction

Bed bugs belong to the insect family of Cimicidae [1]. They feed on the blood of humans and animals [1]. The family includes two cosmopolitan species: Cimex lectularius living in moderate climates, and Cimex hemipterus living mainly in the tropical zone [2]. A female bed bug can reach a length of 7 mm [2]. The male usually has smaller dimensions [3]. It is possible that the amount of blood absorbed significantly exceeds the weight of the parasite, increasing the size and weight of the insect [1, 3]. The bed bug is a flat, brownish-red wingless arthropod [2]. In the literature it is sometimes compared to the seeds of apples [4]. The color of the body is dependent on the stage of satiety. Hungry bed bugs are transparent, while a satiated one can change to a red-brown color [3]. In the region of the third leg pair, bed bugs have glands that secrete an unpleasant odor comparable to the smell of coriander [3, 5]. A mature bed bug feeds usually three to five times daily, dedicating 10 min to each meal [1]. The female bed bug lays about two to three eggs per day, which develop into larvae and nymphs in 1–2 months [3]. In order to reach maturity, nymphs must molt four times, which is possible only after a meal containing blood [4]. Bed bugs can survive without food for a very long time [3]. It is estimated that they can survive without food even for a year [1]. In recent times there have been reports that bed bugs can be a vector for a variety of pathogens such as viruses, bacteria and protozoa [6]. Therefore, detection of these insects is very important from the epidemiological point of view [6–8], especially in cases of emergency pathogens such as Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) [8]. Bed bugs are a likely vector of hepatitis B virus. In the case of viruses such as HIV or hepatitis C virus, the bed bug seems to have no significance [6]. Its role in the transmission of the protozoan Trypanosoma cruzi is not entirely clear [7].

Objective

The aim of this paper is to present two cases: a father and his daughter living in the same household, both with lesions after bed bug bites imitating autoimmune bullous diseases.

Case reports

Case 1

A 57-year-old patient came to the Department of Dermatology for Adults in the Miedzyleski Specialist Hospital in Warsaw in early October 2015. The patient complained of disseminated bullous skin changes. He presented with edematous and erythematous lesions accompanied by severe pruritus. Symptoms had appeared about 3 weeks prior to admission. He was treated in an outpatient clinic with acyclovir and topical ointment containing zinc with no improvement. The patient gave a history of hypothyroidism, prostatic hypertrophy and depression. A few months earlier he moved to a new apartment where he lived with his daughter. On admission the patient presented with pruritic erythematous and edematous skin changes, erosions partially covered with crusts and tense bullae located on both lesional and non-lesional skin of the trunk and upper and lower extremities. Some of the skin changes had a linear arrangement, while others were grouped (Fig. 1). Face, scalp and mucous membranes were free of lesions. Laboratory examinations showed elevated levels of erythrocyte sedimentation rate (ESR), D-dimer, uric acid, total cholesterol and IgE in the serum. A slightly elevated number of eosinophils was present in the blood smear. Bullous pemphigoid was suspected. Direct and indirect immunofluorescence tests were negative. We also performed histopathological examination of the bullous lesion, which revealed epidermis with foci of parakeratosis. Beneath the epidermis there was a bulla filled with fluid and deposits of fibrin. In the subcutaneous tissue inflammatory lymphocytic infiltration around small vessels was present (Fig. 2).
Due to the suspicion of autoimmune bullous disease, treatment with corticosteroids (dexamethasone 8 mg twice daily), tetracycline, antihistamines and topical corticosteroids and emollients was introduced. The patient responded well to the therapy and his condition improved. He was discharged home on topical glucocorticosteroids therapy and emollients. After returning home the patient discovered insects inside the sofa he slept on (Fig. 3). He decided to change the flat. He continued the prescribed medication. At present the patient is being followed up and has clear skin.

Case 2

A woman aged 34 in good general condition attended the Department of Dermatology for Adults in Miedzyleski Specialist Hospital in Warsaw in late October 2015. On admission the patient complained of itchy erythematous and edematous lesions and vesicles in the area of the neck, buttocks, thighs and arms (Fig. 4). These symptoms appeared about 4 weeks prior to admission. The patient lived with her father in a new flat. Laboratory tests showed a slightly elevated level of indirect bilirubin in the serum. Other values were within the normal limits. Direct and indirect immunofluorescence tests were negative. After detailed history taking, insect bite reaction was suspected. The patient was treated with a topical corticosteroid with good results. She did not come for a checkup in the outpatient clinic. Her father informed of complete resolution of symptoms in his daughter.

Discussion

Detailed data on the epidemiology and prevalence of bed bugs in the world are limited [6]. The occurrence of insects is associated with a high population density and poor hygienic conditions [6]. Bed bugs usually are present in the surroundings of households with large population centers, i.e. in hotels, dormitories, hospitals, ships or shelters for the homeless [4, 6, 8–10]. In the latter case, the frequency of bites is about 30% [10]. Bed bugs usually hide in beds, headboards and under mattresses [6]. They move along cables, finding their way through electric sockets [3]. The insects can also easily travel as “stowaways” with people, hidden in clothes, bags or luggage [9]. One way of transmission reported was by furniture [9]. They can travel long distances, settling in new feeding sites [1, 11].
Bed bug bites are painless due to anesthetic substances contained in the insect saliva as well as vasodilator and antithrombotic factors [1, 2]. Skin lesions resulting from insect bites can be erythematous, edematous, papular, in the form of spots and hemorrhagic lesions. Very often they are accompanied by itching. Swelling of the face and bullae are less frequent [3, 11–14]. The bites typically have a linear arrangement which is described in the literature as “breakfast, lunch, dinner”. The reactions are also called “bed bug dermatitis” [11]. Insects usually seek food at night, choosing naked parts of the victim’s body [1, 13]. Bed bug biting usually disturbs sleep [13].
Due to the diverse morphology of lesions, bed bug bites should be differentiated from other diseases. The most commonly taken into account are bites by other arthropods such as mosquitoes or fleas [3]. The differential diagnosis should also consider acute urticaria, papular urticaria, prurigo simplex acuta, erythema multiforme and strophulus [3, 15].
In this paper we wanted to show that bed bug bites may provoke bulla and vesicles, which can mimic bullous diseases such as bullous pemphigoid or Duhring’s disease. In the first patient, we observed tense bullae on both lesional and non-lesional skin. In the second case skin changes were manifested in the form of erythematous and edematous lesions, with associated vesicles. Both the father and his daughter complained of itching.
The diagnosis in both cases was established on the basis of a detailed history, clinical manifestations, presence of insects and improvement after treatment as well as a change of the place of living. A key factor in the first case was the appearance of skin changes in the patient’s daughter in the same period of time, prompting the search for the parasitic etiology. Negative results of direct and indirect immunofluorescence tests excluded autoimmune bullous diseases.

Conflict of interest

The authors declare no conflict of interest.

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Submitted: 24 II 2016
Accepted: 11 VII 2016