Uncommon reasons of the digestive tract-related paraneoplastic syndromes in children with neuroblastic tumors: three case reports

Elżbieta Czkwianianc; Beata Zalewska-Szewczyk; Józef Kobos; Anna Socha-Banasiak; Szymon Janczar; Sylwia Prymus-Kasińska; Joanna Kazanek-Zasada; Wojciech Młynarski

doi:10.5114/wo.2018.74393

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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1/2018
vol. 22

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abstract:

Original paper

Uncommon reasons of the digestive tract-related paraneoplastic syndromes in children with neuroblastic tumors: three case reports

Elżbieta Czkwianianc

,

Beata Zalewska-Szewczyk

,

Józef Kobos

,

Anna Socha-Banasiak

,

Szymon Janczar

,

Sylwia Prymus-Kasińska

,

Joanna Kazanek-Zasada

,

Wojciech Młynarski

Contemp Oncol (Pozn) 2018; 22 (1): 42-46

DOI: https://doi.org/10.5114/wo.2018.74393

Online publish date: 2018/04/03

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AMA

Czkwianianc E, Zalewska-Szewczyk B, Kobos J, et al. Uncommon reasons of the digestive tract-related paraneoplastic syndromes in children with neuroblastic tumors: three case reports. Contemporary Oncology/Współczesna Onkologia. 2018;22(1):42-46. doi:10.5114/wo.2018.74393.

APA

Czkwianianc, E., Zalewska-Szewczyk, B., Kobos, J., Socha-Banasiak, A., Janczar, S.,  & Prymus-Kasińska, S. et al. (2018). Uncommon reasons of the digestive tract-related paraneoplastic syndromes in children with neuroblastic tumors: three case reports. Contemporary Oncology/Współczesna Onkologia, 22(1), 42-46. https://doi.org/10.5114/wo.2018.74393

Chicago

Czkwianianc, Elżbieta, Beata Zalewska-Szewczyk, Józef Kobos, Anna Socha-Banasiak, Szymon Janczar, Sylwia Prymus-Kasińska,  and Joanna Kazanek-Zasada et al. 2018. "Uncommon reasons of the digestive tract-related paraneoplastic syndromes in children with neuroblastic tumors: three case reports". Contemporary Oncology/Współczesna Onkologia 22 (1): 42-46. doi:10.5114/wo.2018.74393.

Harvard

Czkwianianc, E., Zalewska-Szewczyk, B., Kobos, J., Socha-Banasiak, A., Janczar, S., Prymus-Kasińska, S., Kazanek-Zasada, J.,  and Młynarski, W. (2018). Uncommon reasons of the digestive tract-related paraneoplastic syndromes in children with neuroblastic tumors: three case reports. Contemporary Oncology/Współczesna Onkologia, 22(1), pp.42-46. https://doi.org/10.5114/wo.2018.74393

MLA

Czkwianianc, Elżbieta et al. "Uncommon reasons of the digestive tract-related paraneoplastic syndromes in children with neuroblastic tumors: three case reports." Contemporary Oncology/Współczesna Onkologia, vol. 22, no. 1, 2018, pp. 42-46. doi:10.5114/wo.2018.74393.

Vancouver

Czkwianianc E, Zalewska-Szewczyk B, Kobos J, Socha-Banasiak A, Janczar S, Prymus-Kasińska S et al. Uncommon reasons of the digestive tract-related paraneoplastic syndromes in children with neuroblastic tumors: three case reports. Contemporary Oncology/Współczesna Onkologia. 2018;22(1):42-46. doi:10.5114/wo.2018.74393.

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Aim of the study
presentation of the uncommon paraneoplastic syndromes related to the gastrointestinal tract that may occur in children with neuroblastic tumors and their impact on the disease course.

Material and methods
Retrospective analysis of three cases of patients mainly with digestive tract-related symptoms, who were originally admitted to the gastroenterology department from 2013 to 2016 and were finally diagnosed with neuroblastic tumors.

Results
The clinical data analysis showed that the symptoms from gastrointestinal tract were dominant in analyzed subjects. The first case is a girl with weight loss, bloating and severe diarrhea, admitted to the hospital in a state of dehydration. The laboratory tests revealed severe hypokalemia. Finally, vasoactive intestinal peptide (VIP) secreting ganglioneuroblastoma was diagnosed and effective surgery was performed. The second case was also a girl who suffered from the incidents of watery diarrhea and flatulence. The tumor was detected by computerized tomography scan. The 3rd stage of ganglioneuroblastoma was diagnosed. The patient required chemotherapy, radiotherapy and surgery treatment. The third child was a boy, hospitalized due to abdominal pain, constipation and weakness. During the diagnostic process, the 4th stage of neuroblastoma was recognized. The chemotherapy, surgery, radiotherapy and immunotherapy were applied.

Conclusions
In children with common abdominal symptoms as chronic flatulence, diarrhea or severe constipation of unknown etiology, the neuroblastic tumors should be considered.

keywords:

Uncommon reasons of the digestive tract-related paraneoplastic syndromes in children with neuroblastic tumors: three case reports

Elżbieta Czkwianianc , Beata Zalewska-Szewczyk , Józef Kobos , Anna Socha-Banasiak , Szymon Janczar , Sylwia Prymus-Kasińska , Joanna Kazanek-Zasada , Wojciech Młynarski

neuroblastic tumors, VIP-secreting tumor, paraneoplastic syndrome, diarrhea, constipation

Elżbieta Czkwianianc

,

Beata Zalewska-Szewczyk

,

Józef Kobos

,

Anna Socha-Banasiak

,

Szymon Janczar

,

Sylwia Prymus-Kasińska

,

Joanna Kazanek-Zasada

,

Wojciech Młynarski