Unexpected cause of headache in a patient with Noonan syndrome: aseptic meningitis

Hacer Efnan Melek Arsoy; Öner Özdemir; Ümmügülsüm Dikici; Ece Tüsüz Önata; Recep Polat

doi:10.5114/pja.2024.142944

eISSN: 2391-6052
ISSN: 2353-3854

Alergologia Polska - Polish Journal of Allergology

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4/2024
vol. 11

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abstract:

Case report

Unexpected cause of headache in a patient with Noonan syndrome: aseptic meningitis

Hacer Efnan Melek Arsoy

¹

,

Öner Özdemir

²

,

Ümmügülsüm Dikici

²

,

Ece Tüsüz Önata

²

,

Recep Polat

³

Department of Pediatrics, Faculty of Medicine, Sakarya University, Sakarya Training and Research Hospital, Sakarya, Türkiye
Department of Pediatric Immunology and Allergic Diseases, Faculty of Medicine, Sakarya University, Sakarya Training and Research Hospital, Sakarya, Türkiye
Division of Pediatric Endocrinology, Faculty of Medicine, Sakarya University, Sakarya Training and Research Hospital, Sakarya, Türkiye

Alergologia Polska – Polish Journal of Allergology 2024; 11, 4: 327–331

DOI: https://doi.org/10.5114/pja.2024.142944

Online publish date: 2024/09/13

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Malignancies, autoimmune diseases, viral and fungal infections, as well as aseptic meningitis due to certain drugs are frequently seen. Antibiotics, intravenous immunoglobulin (IVIG), non-steroidal anti-inflammatory drugs are often considered responsible. The incidence following IVIG infusion is 0.067%; however, symptoms may start to show up anywhere from 6 h to 4 days following infusion. It is challenging to diagnose and is easily overlooked because of symptoms and clinical findings that might arise from a variety of conditions, including headaches, stiff necks, and vomiting. We present a patient with Noonan syndrome who was diagnosed with common variable immunodeficiency due to recurrent illness, had IVIG replacement therapy, and developed aseptic meningitis following the initial course of treatment. No similar case has been documented before in the literature. Noonan syndrome may also be related with an increased incidence of IVIG-associated aseptic meningitis, while the explanation for this association is unclear.

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Unexpected cause of headache in a patient with Noonan syndrome: aseptic meningitis

Hacer Efnan Melek Arsoy 1 , Öner Özdemir 2 , Ümmügülsüm Dikici 2 , Ece Tüsüz Önata 2 , Recep Polat 3

aseptic meningitis, intravenous immunoglobulin, Noonan syndrome

Hacer Efnan Melek Arsoy

¹

,

Öner Özdemir

²

,

Ümmügülsüm Dikici

²

,

Ece Tüsüz Önata

²

,

Recep Polat

³