en POLSKI
eISSN: 2300-8660
ISSN: 0031-3939
Pediatria Polska - Polish Journal of Paediatrics
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

4/2019
vol. 94
 
Share:
Send email
Share:
abstract:
Case report

Unusual cause of skin nodules in a child – case report

Michalina Horochowska
1
,
Jacek Jagiełło
2
,
Jadwiga Węcławek-Tompol
1
,
Marta Rzeszutko
3
,
Anna Zimny
2
,
Marek Ussowicz
1
,
Bernarda Kazanowska
1

  1. Department of Paediatric Bone Marrow Transplantation, Oncology, and Haematology, Wroclaw Medical University, Wroclaw, Poland
  2. Department of General and Interventional Radiology and Neuroradiology, Wroclaw Medical University, Wroclaw, Poland
  3. Department of Pathomorphology, Wroclaw Medical University, Wroclaw, Poland
Pediatr Pol 2019; 94 (4): 271–275
DOI: https://doi.org/10.5114/polp.2019.88050
Online publish date: 2019/09/19
View full text Get citation
 
PlumX metrics:
We report a four-year-old boy with a skin lesion that was misdiagnosed as an abscess and unsuccessfully treated with systemic antibiotics and drainage. Due to its progression, the child underwent a biopsy, which revealed myeloid sarcoma. The histopathological verification at the referral centre changed the diagnosis to an anaplastic large-cell lymphoma (ALCL) with internal organ involvement. This subtype of paediatric lymphoma usually manifests as a systemic disease, and isolated skin infiltration is rare. The patient was treated according to the ALCL-99 protocol and achieved remission. Five months later a systemic lymph-node relapse was diagnosed. Salvage chemotherapy was administered and allogeneic stem cell transplantation was performed, which resulted in sustained remission. Skin infiltrates are commonly seen in children, and routine diagnostics is usually sufficient for a proper medical care. The diagnostic difficulties in the reported patient emphasise the need for observation and invasive diagnostics in non-responding cases.
keywords:

T-cell lymphoma, anaplastic large-cell lymphoma, anaplastic lymphoma kinase, CD30+