Uterine myoma with massive lymphocytic infiltration – case report

Tomasz Wasyluk; Bogdan Obrzut; Krystyna Gałązka; Marcin Żmuda; Marzanna Obrzut; Dorota Darmochwał-Kolarz

doi:10.5114/pm.2019.86838

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

2/2019
vol. 18

Send email

Copy url:

abstract:

Case report

Uterine myoma with massive lymphocytic infiltration – case report

Tomasz Wasyluk

¹

,

Bogdan Obrzut

¹

,

Krystyna Gałązka

²

,

Marcin Żmuda

³

,

Marzanna Obrzut

⁴

,

Dorota Darmochwał-Kolarz

^{1, 5}

Department of Obstetrics and Gynaecology, Provincial Clinical Hospital No. 2 in Rzeszow, Poland
Department of Pathomorphology, Jagiellonian University Medical College, Krakow, Poland
Department of Clinical Pathomorphology, Provincial Clinical Hospital No. 2 in Rzeszow, Poland
Institute of Nursing and Health Sciences, Faculty of Medicine, University of Rzeszow, Poland
Department of Gynaecology and Obstetrics, Institute of Experimental and Clinical Medicine, Faculty of Medicine, University of Rzeszow, Poland

Menopause Rev 2019; 18(2): 123-125

DOI: https://doi.org/10.5114/pm.2019.86838

Online publish date: 2019/06/28

View full text Get citation

PlumX metrics:

Introduction
Uterine leiomyomas are the most common neoplasm of the uterus in women. Massive lymphocytic infiltration in a myoma is an unusual finding. It is characterised by the varying intensity of lymphocyte infiltration, the presence of scattered plasma cells, eosinophilia, and rarely, other items. We would like to call attention to such a rare lesion.

Case description
We present the case of a 31-year-old woman who had undergone surgical excision of a uterine tumour. Grossly, it had the typical uterine smooth muscle wall consistency. The microscopic examination revealed leiomyoma with heavy infiltration composed mainly of lymphocytes. On immunohistochemistry, in the lymphocytic infiltrate the T mature (CD3+/CD5+/TdT–) lymphocytes, small and of cytotoxic (CD8+/CD56–) type, prevailed, with moderate proliferative activity (expression of Ki67 found in ca. 30-40% of the cells), whereas B lymphocytes (CD20+/CD5–/TdT–) were innumerous and present in nodular aggregates. Despite a strong suspicion of neoplastic lymphoproliferation, the histopathological diagnosis was: leiomyoma with massive lymphoid infiltration. The cause of this feature is not known, although the gonadotropin-releasing hormone agonist and post-menopausal processes may promote such transformations. In differential diagnosis, malignant lymphoma, inflammatory pseudotumour, and pyomyoma should be included.

Conclusions
Lymphocytic infiltration within the uterine myoma is rare. The recognition of its distinct histological features is important to avoid possible misdiagnosis.

keywords:

Uterine myoma with massive lymphocytic infiltration – case report

Tomasz Wasyluk 1 , Bogdan Obrzut 1 , Krystyna Gałązka 2 , Marcin Żmuda 3 , Marzanna Obrzut 4 , Dorota Darmochwał-Kolarz 1, 5

myoma, leiomyoma, lymphoma, neoplasms, gonadotropins, menopause

Tomasz Wasyluk

¹

,

Bogdan Obrzut

¹

,

Krystyna Gałązka

²

,

Marcin Żmuda

³

,

Marzanna Obrzut

⁴

,

Dorota Darmochwał-Kolarz

^{1, 5}