VEGF-C expression is not a prognostic factor in locally advanced colon adenocarcinoma

Mariusz Szajewski; Wiesław Janusz Kruszewski; Joanna Lakomy; Maciej Ciesielski; Krzysztof Kawecki; Jarosław Szefel

doi:10.5114/wo.2015.56649

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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6/2015
vol. 19

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abstract:

Original paper

VEGF-C expression is not a prognostic factor in locally advanced colon adenocarcinoma

Mariusz Szajewski

,

Wiesław Janusz Kruszewski

,

Joanna Lakomy

,

Maciej Ciesielski

,

Krzysztof Kawecki

,

Jarosław Szefel

Contemp Oncol (Pozn) 2015; 19 (6): 446–450

DOI: https://doi.org/10.5114/wo.2015.56649

Online publish date: 2016/01/13

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Aim of the study: Evaluation of the relationships between increased expression of VEGF-C (vascular endothelial growth factor-C) and vessel density in the tumour-surrounding stroma, patient survival, and other conventional prognostic factors in patients with pT3-4 colon cancer.

Material and methods: Expression of VEGF-C and vessel density were immunohistochemically assessed in 104 specimens of primary, locally advanced (pT3-4) colon adenocarcinoma after surgical resection.

Results: A significant relationship was found between the expression of VEGF-C and increased vessel density in the tumour-surrounding stroma (p = 0.03). A relationship between VEGF-C expression and location of the tumour in the left side of the colon was also found (p = 0.003). Expression of VEGF-C was likely to occur in well-differentiated tumours. No relationship between patient overall survival and the expression level of VEGF-C in locally advanced colon cancer was observed.

Conclusions: The study results indicate that expression of VEGF-C in cells of locally advanced pT3-4 adenocarcinoma of the colon does not affect the survival time of the patients. Increased expression of VEGF-C is accompanied by a significant increase in vessel density in the pT3-4 tumour stroma. Increased expression of VEGF-C in cancer cells is related to the tumour location in the left side of the colon and better tumour differentiation.

keywords:

VEGF-C expression is not a prognostic factor in locally advanced colon adenocarcinoma

Mariusz Szajewski , Wiesław Janusz Kruszewski , Joanna Lakomy , Maciej Ciesielski , Krzysztof Kawecki , Jarosław Szefel

VEGF-C, vessel density, survival, colon cancer, angiogenesis, lymphangiogenesis

Mariusz Szajewski

,

Wiesław Janusz Kruszewski

,

Joanna Lakomy

,

Maciej Ciesielski

,

Krzysztof Kawecki

,

Jarosław Szefel