eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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3/2023
vol. 74
 
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Vaginal metastasis of renal clear cell carcinoma: a case report emphasizing the role of immunohistochemistry in differential diagnosis in the absence of a clinical history

Simona Stolnicu
1
,
Andrei Patrichi
1
,
Francisc Rozsnyai
2
,
Robert A. Soslow
3

  1. Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Targu Mures, Romania
  2. Department of Gynecology and Obstetrics, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Romania
  3. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Pol J Pathol 2023; 74 (3): 216-218
DOI: https://doi.org/10.5114/pjp.2023.132229
Online publish date: 2023/10/25
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We present the case of a 71-year-old patient, with vaginal bleeding, dyspnea, headache, loss of appetite and weakness. Clinical examination revealed a pediculated vaginal mass of 25 mm diameter, of dark-red color and soft spongy consistency, with an ulcerated surface and originating from the anterior wall, which was surgically removed. The morphology was dominanted by large, round to polygonal tumor cells, arranged in a predominantly tubulo-cystic architecture, surrounding numerous blood vessels that dominated the appearance, suggesting a perivascular epithelioid cell tumor (PEComa) or hemangioblastoma but the presence of pleomorphic nuclei, numerous mitoses together with immunohistochemistry helped for a correct diagnosis of vaginal .
keywords:

vaginal metastasis, renal cell carcinoma, immunohistochemistry
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