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Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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1/2021
vol. 38
 
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abstract:
Original paper

Variability of the rs333 in Polish patients with lupus erythematosus

Dominika Mlicka
1
,
Anna Duleba
1
,
Rafal Czajkowski
2
,
Mariusz Gawrych
2
,
Anna Woźniacka
3
,
Ewa Robak
3
,
Marta Gorzkiewicz
1
,
Szymon Kozłowski
4
,
Tomasz Grzybowski
1
,
Katarzyna Skonieczna
1

  1. Department of Forensic Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
  2. Department of Dermatology and Venereology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
  3. Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland
  4. Independent researcher
Adv Dermatol Allergol 2021; XXXVIII (1): 131-136
DOI: https://doi.org/10.5114/ada.2021.104288
Online publish date: 2021/03/10
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Introduction
Lupus erythematosus (LE) is an autoimmune disease with a strong influence of genetic and environmental factors. C-C motif chemokine receptor 5 (CCR5) gene expression may affect the development and intensity of LE. Aim: To evaluate the possible association between the 32bp deletion in rs333 locus located within the CCR5 gene and the development of LE or the occurrence of various clinical symptoms in the course of the disease.

Material and methods
One hundred and twenty patients with LE (77 with systemic lupus erythematosus (SLE) and 43 with discoid lupus erythematosus (DLE)) and 100 healthy controls from the Polish population were genotyped for deletion in rs333.

Results
32 bp deletion in the rs333 was significantly more frequent among healthy individuals than DLE patients. Moreover, heterozygotes and homozygotes with deletion in rs333 were significantly more frequent within the control group than the group of patients with discoid lupus erythematosus. In contrast, any statistically significant differences in allele or genotype frequencies between healthy persons and SLE patients were observed. Furthermore, nucleotide sequence variability of rs333 was not associated with certain clinical symptoms of LE patients.

Conclusions
Deletion in the rs333 might be a protective factor for DLE, but not SLE in the Polish population. Nevertheless further studies performed on larger populations are needed to confirm these observations.

keywords:

lupus erythematosus, systemic lupus erythematosus, discoid lupus erythematosus, CCR5 gene, rs333
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