Vitamin B6 improves blood parameters in rats fed a protein-deficient diet and subjected to moderate, long-term exercise

Bolesław Kalicki; Aneta Lewicka; Krystyna Jęderka; Monika Leśniak; Justyna Marszałkowska-Jakubik; Sławomir Lewicki

doi:10.5114/ceji.2019.83266

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

1/2019
vol. 44

Send email

Copy url:

abstract:

Experimental immunology

Vitamin B6 improves blood parameters in rats fed a protein-deficient diet and subjected to moderate, long-term exercise

Bolesław Kalicki

¹

,

Aneta Lewicka

²

,

Krystyna Jęderka

³

,

Monika Leśniak

³

,

Justyna Marszałkowska-Jakubik

²

,

Sławomir Lewicki

³

Paediatric, Nephrology and Allergology Clinic, Military Institute of Medicine, Warsaw, Poland
Laboratory of Epidemiology, Military Institute of Hygiene and Epidemiology, Warsaw, Poland
Department of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology, Warsaw, Poland

(Centr Eur J Immunol 2019; 44 (1): 23-32)

DOI: https://doi.org/10.5114/ceji.2019.83266

Online publish date: 2019/03/11

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Kalicki B, Lewicka A, Jęderka K, Leśniak M, Marszałkowska-Jakubik J, Lewicki S. Vitamin B6 improves blood parameters in rats fed a protein-deficient diet and subjected to moderate, long-term exercise. Central European Journal of Immunology. 2019;44(1):23-32. doi:10.5114/ceji.2019.83266.

APA

Kalicki, B., Lewicka, A., Jęderka, K., Leśniak, M., Marszałkowska-Jakubik, J.,  & Lewicki, S. (2019). Vitamin B6 improves blood parameters in rats fed a protein-deficient diet and subjected to moderate, long-term exercise. Central European Journal of Immunology, 44(1), 23-32. https://doi.org/10.5114/ceji.2019.83266

Chicago

Kalicki, Bolesław, Aneta Lewicka, Krystyna Jęderka, Monika Leśniak, Justyna Marszałkowska-Jakubik,  and Sławomir Lewicki. 2019. "Vitamin B6 improves blood parameters in rats fed a protein-deficient diet and subjected to moderate, long-term exercise". Central European Journal of Immunology 44 (1): 23-32. doi:10.5114/ceji.2019.83266.

Harvard

Kalicki, B., Lewicka, A., Jęderka, K., Leśniak, M., Marszałkowska-Jakubik, J.,  and Lewicki, S. (2019). Vitamin B6 improves blood parameters in rats fed a protein-deficient diet and subjected to moderate, long-term exercise. Central European Journal of Immunology, 44(1), pp.23-32. https://doi.org/10.5114/ceji.2019.83266

MLA

Kalicki, Bolesław et al. "Vitamin B6 improves blood parameters in rats fed a protein-deficient diet and subjected to moderate, long-term exercise." Central European Journal of Immunology, vol. 44, no. 1, 2019, pp. 23-32. doi:10.5114/ceji.2019.83266.

Vancouver

Kalicki B, Lewicka A, Jęderka K, Leśniak M, Marszałkowska-Jakubik J, Lewicki S. Vitamin B6 improves blood parameters in rats fed a protein-deficient diet and subjected to moderate, long-term exercise. Central European Journal of Immunology. 2019;44(1):23-32. doi:10.5114/ceji.2019.83266.

PlumX metrics:

Vitamin B6 is necessary for many enzymatic pathways (glucose and lipid metabolism, DNA/RNA synthesis, or modulation of gene expression) and affects immune cell function and blood-forming processes. We hypothesised that supplementing a protein-deficient diet with vitamin B6 may reduce the negative impact of protein malnutrition. Here, we evaluated the effect of moderate, long-term exercise (ninety days) on selected blood parameters in rats fed a normal diet, a protein-deficient diet, or a protein-deficient diet supplemented with vitamin B6. Selected haematological, immunological, and biochemical parameters were examined. A protein-deficient diet lasting 90 days caused significant reduction in body mass, increased activity of aminotransferases (asparagine and alanine), an increased percentage of innate cells in the blood, and decreased haemoglobin concentration in the blood. Adding vitamin B6 significantly increased body and muscle mass, decreased liver parameters, and caused normalisation of haemoglobin concentration and the proportion of white blood cells in the blood. These results indicate that vitamin B6 supplementation significantly improves the health of protein-malnourished rats and paves the way for the development of novel anti-malnutrition therapies.

keywords:

Vitamin B6 improves blood parameters in rats fed a protein-deficient diet and subjected to moderate, long-term exercise

Bolesław Kalicki 1 , Aneta Lewicka 2 , Krystyna Jęderka 3 , Monika Leśniak 3 , Justyna Marszałkowska-Jakubik 2 , Sławomir Lewicki 3

rats, exercise, immunology, protein deficiency, vitamin B6, blood parameters

Bolesław Kalicki

¹

,

Aneta Lewicka

²

,

Krystyna Jęderka

³

,

Monika Leśniak

³

,

Justyna Marszałkowska-Jakubik

²

,

Sławomir Lewicki

³