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eISSN: 2083-8441
ISSN: 2081-237X
Pediatric Endocrinology Diabetes and Metabolism
Bieżący numer Archiwum Artykuły zaakceptowane O czasopiśmie Suplementy Rada naukowa Recenzenci Bazy indeksacyjne Prenumerata Kontakt Zasady publikacji prac Opłaty publikacyjne Standardy etyczne i procedury
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SCImago Journal & Country Rank
3/2023
vol. 29
 
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Artykuł oryginalny

Wpływ doustnych probiotyków na poziomy hemoglobiny glikowanej u dzieci z cukrzycą typu 1 – badanie kliniczne z randomizacją

Hosein Shabani-Mirzaee
1
,
Zahra Haghshenas
1
,
Armen Malekiantaghi
2
,
Mohsen Vigeh
3
,
Fazeleh Mahdavi
1
,
Kambiz Eftekhari
2, 4

  1. Department of Pediatric Endocrinology, Tehran University of Medical Sciences, Tehran, Iran
  2. Pediatrics, Tehran University of Medical Sciences, Iran
  3. Maternal-Fetal Medicine Research Center, Tehran University of Medical Sciences, Iran
  4. Pediatric Gastroenterology and Hepatology Research Center, Tehran University of Medical Sciences, Iran
Pediatr Endocrinol Diabetes Metab 2023; 29 (3): 128-133
Data publikacji online: 2023/10/23
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Introduction
Proper control of blood glucose in children with type 1 diabetes has a direct effect on their metabolism and quality of life by reducing the risk of complications. The use of probiotics may have a beneficial effect on glucose levels.

Purpose
The aim of this study was to evaluate the effect of oral consumption of probiotics on glycosylated haemoglobin in children with type 1 diabetes.

Material and methods
In this single-blind randomized controlled clinical trial, 52 children with type 1 diabetes were studied. We created 2 groups of 26 individuals each. The probiotic group received a daily probiotic capsule for 90 days, in addition to routine insulin therapy. The control group received only insulin therapy. Blood samples were taken to measure HbA1c, fasting plasma glucose, and lipid profiles at the beginning and end of the trial.

Results
The study showed that HbA1c was high in both groups, but this increase was lower in the probiotic group than in the control group. This difference was not statistically significant. The mean level of fasting plasma glucose in the probiotic group was significantly reduced compared to the control group (p = 0.016).

Conclusions
According to the results of our study, consumption of oral probiotics has no significant effect on HbA1c levels in children with type 1 diabetes mellitus.


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