Bieżący suplement Archiwum Klinika Oczna |
3/2004
vol. 106 streszczenie artykułu:
Artykuł oryginalny
Zjawiska immunologiczne prowadzące do patologii filmu łzowego. Czy cyklosporyna będzie przełomem w leczeniu zespołu Sjögrena? Doniesienie wstępne
Agnieszka Kujawa
1
,
Radosław Różycki
1
KLINIKA OCZNA 2004, Supl. 3: S489–S491
Data publikacji online: 2022/12/29
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Purpose The purpose of this study is to examine the new way in the casual treatment, resulting in the normalization of immunological processes on the ocular surface. Material and methods 5 patients (4 women and 1 men with mean age of 55,5 years, range 45 to 59 years) with Sjögren’s syndrome – type dry eye, were included in the study. Patients received topically 0,05% cyclosporine, ophthalmic emulsion twice a day for a 6 months. The severity of patients complaints was evaluated according to the Dr. Mann Pharma / Bausch & Lomb’s record. Results Schirmer test II values, and lyzamine green staining scores, were evaluated priori to treatment and 6 months after the start. At the beginning of the study (day 0) the Schirmer test II values ranged from 1 to 5 mm (mean – 2,2 mm). Break-up-time ranged from 3 to 6 sec (mean – 4,8 sec). In all of 5 cases lyzamine green staining scores were 9. On month 6th, all of 5 patients had significant differences, compared to their baseline measurements in term of above mentioned parameters. The Schirmer test II values ranged from 8 to 12 mm (mean – 10,3 mm). Break-up-time ranged from 9 to 13 sec (mean – 11,2 sec), lyzamine green staining scores ranged from 2 to 3 points (mean – 2,7). Conclusions 0,05% cyclosporine, ophthalmic emulsion had a beneficial effect both on the subjective and objective clinical parameters of dry eye patients. The final conclusions must be supported by more cases. |