The role of TCR-z expression in immunosuppression induced by tumour

Jan Sikora

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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5/2009
vol. 13

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abstract:

Review paper

The role of TCR-z expression in immunosuppression induced by tumour

Jan Sikora

Współczesna Onkologia (2009) vol. 13; 5 (221–226)

Online publish date: 2009/11/18

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The z-chain is a 16-kDa molecule associated with the T-cell receptor TCR-CD3 complex in T lymphocytes and FcgRIII in NK cells. The z functions as a transmembrane signaling molecule. Several distinct mechanisms may be responsible for decreased/absent z in T cells of patients with cancer. Assessment of z-chain expression in the course of various diseases shows changes in expression of this molecule in immune cells. Immunohistochemical evaluation of z expression can link it to the conventional markers of prognosis or survival. Monitoring for z expression is useful for assessing immune competence in these patients and for following changes in immune competence during anticancer therapies. Correlations made between clinical findings, pathologic results, and z expression in immune cells suggest that low/absent z is predictive of poor prognosis and survival in patients with cancer.

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The role of TCR-z expression in immunosuppression induced by tumour

Jan Sikora

T lymphocytes, z-chain expression, cancers