The significance of DNA mismatch repair (MMR) in breast cancer

Hanna Romanowicz; Beata Smolarz; Tomasz Fiks; Andrzej Kulig; Ireneusz Połać; Anna Sobczuk; Tomasz Pertyński

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

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2/2010
vol. 9

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abstract:

Review paper

The significance of DNA mismatch repair (MMR) in breast cancer

Hanna Romanowicz

,

Beata Smolarz

,

Tomasz Fiks

,

Andrzej Kulig

,

Ireneusz Połać

,

Anna Sobczuk

,

Tomasz Pertyński

Przegląd Menopauzalny 2010; 2: 95–100

Online publish date: 2010/05/12

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Background: Microsatellite instability (MSI) is due to defective DNA mismatch repair. Defects in DNA mismatch-repair (MMR) genes lead to replication errors revealed as instability in microsatellite markers. Studies have shown that breast cancer may be associated with mutations in mismatch repair genes, such as MSH2, MSH3, MSH4, MSH6, MLH1, MLH3, PMS1 and MUTYH.

Aim: Results from studies that assayed MMR in sporadic breast cancer are reviewed.

Conclusion: Several data suggest that microsatellite instability seems to be a risk factor for breast cancer in subjects belonging to HNPCC (hereditary non-polyposis colorectal cancer) families with high incidence of this cancer and sporadic breast cancer.

keywords:

The significance of DNA mismatch repair (MMR) in breast cancer

Hanna Romanowicz , Beata Smolarz , Tomasz Fiks , Andrzej Kulig , Ireneusz Połać , Anna Sobczuk , Tomasz Pertyński

MMR, DNA repair, breast cancer

Hanna Romanowicz

,

Beata Smolarz

,

Tomasz Fiks

,

Andrzej Kulig

,

Ireneusz Połać

,

Anna Sobczuk

,

Tomasz Pertyński