AGTR2 and sprint/power performance: a case-control replication
study for rs11091046 polymorphism in two ethnicities

Thomas P. Yvert; Hirofumi Zempo; Leysan J. Gabdrakhmanova; Naoki Kikuchi; Eri Miyamoto-Mikami; Haruka Murakami; Hisashi Naito; Pawel Cieszczyk; Katarzyna Leznicka; Elena S. Kostryukova; Dmitry G. Alexeev; Emiliya S. Egorova; Agnieszka Maciejewska-Skrendo; Andrey K. Larin; Edward V. Generozov; Nickolay A. Kulemin; Elena A. Ospanova; Alexander V. Pavlenko; Marek Sawczuk; Piotr Zmijewski; Ewelina Lulinska-Kuklik; Vadim M. Govorun; Motohiko Miyachi; Ildus I. Ahmetov; Noriyuki Fuku

doi:10.5114/biolsport.2018.71599

eISSN: 2083-1862
ISSN: 0860-021X

Biology of Sport

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abstract:

Original paper

AGTR2 and sprint/power performance: a case-control replication study for rs11091046 polymorphism in two ethnicities

Thomas P. Yvert

,

Hirofumi Zempo

,

Leysan J. Gabdrakhmanova

,

Naoki Kikuchi

,

Eri Miyamoto-Mikami

,

Haruka Murakami

,

Hisashi Naito

,

Pawel Cieszczyk

,

Katarzyna Leznicka

,

Elena S. Kostryukova

,

Dmitry G. Alexeev

,

Emiliya S. Egorova

,

Agnieszka Maciejewska-Skrendo

,

Andrey K. Larin

,

Edward V. Generozov

,

Nickolay A. Kulemin

,

Elena A. Ospanova

,

Alexander V. Pavlenko

,

Marek Sawczuk

,

Piotr Zmijewski

,

Ewelina Lulinska-Kuklik

,

Vadim M. Govorun

,

Motohiko Miyachi

,

Ildus I. Ahmetov

,

Noriyuki Fuku

Biol Sport. 2018;35(2):105–109

DOI: https://doi.org/10.5114/biolsport.2018.71599

Online publish date: 2018/02/08

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AMA

Yvert T, Zempo H, Gabdrakhmanova L, et al. AGTR2 and sprint/power performance: a case-control replication
study for rs11091046 polymorphism in two ethnicities. Biology of Sport. 2018;35(2):105-109. doi:10.5114/biolsport.2018.71599.

APA

Yvert, T., Zempo, H., Gabdrakhmanova, L., Kikuchi, N., Miyamoto-Mikami, E.,  & Murakami, H. et al. (2018). AGTR2 and sprint/power performance: a case-control replication
study for rs11091046 polymorphism in two ethnicities. Biology of Sport, 35(2), 105-109. https://doi.org/10.5114/biolsport.2018.71599

Chicago

Yvert, Thomas P., Hirofumi Zempo, Leysan J. Gabdrakhmanova, Naoki Kikuchi, Eri Miyamoto-Mikami, Haruka Murakami,  and Hisashi Naito et al. 2018. "AGTR2 and sprint/power performance: a case-control replication
study for rs11091046 polymorphism in two ethnicities". Biology of Sport 35 (2): 105-109. doi:10.5114/biolsport.2018.71599.

Harvard

Yvert, T., Zempo, H., Gabdrakhmanova, L., Kikuchi, N., Miyamoto-Mikami, E., Murakami, H., Naito, H., Cieszczyk, P., Leznicka, K., Kostryukova, E., Alexeev, D., Egorova, E., Maciejewska-Skrendo, A., Larin, A., Generozov, E., Kulemin, N., Ospanova, E., Pavlenko, A., Sawczuk, M., Zmijewski, P., Lulinska-Kuklik, E., Govorun, V., Miyachi, M., Ahmetov, I.,  and Fuku, N. (2018). AGTR2 and sprint/power performance: a case-control replication
study for rs11091046 polymorphism in two ethnicities. Biology of Sport, 35(2), pp.105-109. https://doi.org/10.5114/biolsport.2018.71599

MLA

Yvert, Thomas P. et al. "AGTR2 and sprint/power performance: a case-control replication
study for rs11091046 polymorphism in two ethnicities." Biology of Sport, vol. 35, no. 2, 2018, pp. 105-109. doi:10.5114/biolsport.2018.71599.

Vancouver

Yvert T, Zempo H, Gabdrakhmanova L, Kikuchi N, Miyamoto-Mikami E, Murakami H et al. AGTR2 and sprint/power performance: a case-control replication
study for rs11091046 polymorphism in two ethnicities. Biology of Sport. 2018;35(2):105-109. doi:10.5114/biolsport.2018.71599.

PlumX metrics:

We aimed to replicate, in a specific athletic event cohort (only track and field) and in two different ethnicities (Japanese and East European, i.e. Russian and Polish), original findings showing the association of the angiotensin-II receptor type-2 gene (AGTR2) rs11091046 A>C polymorphism with athlete status. We compared genotypic frequencies of the AGTR2 rs11091046 polymorphism among 282 track and field sprint/power athletes (200 men and 82 women), including several national record holders and Olympic medallists (214 Japanese, 68 Russian and Polish), and 2024 control subjects (842 men and 1182 women) (804 Japanese, 1220 Russian and Polish). In men, a meta-analysis from the two combined cohorts showed a significantly higher frequency of the C allele in athletes than in controls (odds ratio: 1.62, P=0.008, heterogeneity index I 2=0%). With regard to respective cohorts, C allele frequency was higher in Japanese male athletes than in controls (67.7% vs. 55.9%, P=0.022), but not in Russian/Polish male athletes (61.9% vs. 51.0%, P=0.172). In women, no significant results were obtained by meta-analysis for the two cohorts combination (P=0.850). The AC

genotype frequency was significantly higher in Russian/Polish women athletes than in controls (69.2% vs. 42.1%, P=0.022), but not in Japanese women athletes (P=0.226). Our results, in contrast to previous findings, suggested by meta-analysis that the C allele of the AGTR2 rs11091046 polymorphism is associated with sprint/power track and field athlete status in men, but not in women.

keywords:

AGTR2 and sprint/power performance: a case-control replication study for rs11091046 polymorphism in two ethnicities

Renin-angiotensin system, AGTR2, Track and field, Sprint, Power, Physical performance