Case report<br>Severe intrahepatic cholestasis and liver failure after stanozolol usage – case report and review of the literature

Piotr M. Stępień; Katarzyna Reczko; Anna Wieczorek; Dorota Zarębska-Michaluk; Paweł Pabjan; Teodora Król; Wiesław Kryczka

doi:10.5114/ceh.2015.51376

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Case report
Severe intrahepatic cholestasis and liver failure after stanozolol usage – case report and review of the literature

Piotr M. Stępień

,

Katarzyna Reczko

,

Anna Wieczorek

,

Dorota Zarębska-Michaluk

,

Paweł Pabjan

,

Teodora Król

,

Wiesław Kryczka

Clinical and Experimental Hepatology 2015; 1: 30–33

DOI: https://doi.org/10.5114/ceh.2015.51376

Online publish date: 2015/04/30

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AMA

Stępień P, Reczko K, Wieczorek A, et al. Case reportSevere intrahepatic cholestasis and liver failure after stanozolol usage – case report and review of the literature. Clinical and Experimental Hepatology. 2015;1(1):30-33. doi:10.5114/ceh.2015.51376.

APA

Stępień, P., Reczko, K., Wieczorek, A., Zarębska-Michaluk, D., Pabjan, P.,  & Król, T. et al. (2015). Case reportSevere intrahepatic cholestasis and liver failure after stanozolol usage – case report and review of the literature. Clinical and Experimental Hepatology, 1(1), 30-33. https://doi.org/10.5114/ceh.2015.51376

Chicago

Stępień, Piotr M., Katarzyna Reczko, Anna Wieczorek, Dorota Zarębska-Michaluk, Paweł Pabjan, Teodora Król,  and Wiesław Kryczka. 2015. "Case reportSevere intrahepatic cholestasis and liver failure after stanozolol usage – case report and review of the literature". Clinical and Experimental Hepatology 1 (1): 30-33. doi:10.5114/ceh.2015.51376.

Harvard

Stępień, P., Reczko, K., Wieczorek, A., Zarębska-Michaluk, D., Pabjan, P., Król, T.,  and Kryczka, W. (2015). Case reportSevere intrahepatic cholestasis and liver failure after stanozolol usage – case report and review of the literature. Clinical and Experimental Hepatology, 1(1), pp.30-33. https://doi.org/10.5114/ceh.2015.51376

MLA

Stępień, Piotr M. et al. "Case reportSevere intrahepatic cholestasis and liver failure after stanozolol usage – case report and review of the literature." Clinical and Experimental Hepatology, vol. 1, no. 1, 2015, pp. 30-33. doi:10.5114/ceh.2015.51376.

Vancouver

Stępień P, Reczko K, Wieczorek A, Zarębska-Michaluk D, Pabjan P, Król T et al. Case reportSevere intrahepatic cholestasis and liver failure after stanozolol usage – case report and review of the literature. Clinical and Experimental Hepatology. 2015;1(1):30-33. doi:10.5114/ceh.2015.51376.

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Stanozolol is a 17α-alkylated synthetic anabolic steroid used illegally by bodybuilders. We present a 19-year-old man who was taking 50 mg of stanozolol intramuscularly, every other day for 2 months, to improve muscle mass. On admission, his bilirubin concentration was 44.34 mg/dl. The serum levels of liver enzymes were normal, with only alanine aminotransferase being slightly elevated. Liver biopsy revealed toxic hepatitis of minor grade with periportal fibrosis and intrahepatic cholestasis. Medical treatment of the patient was conservative. Despite the therapy the patient’s general condition deteriorated – bilirubin level increased to 56.64 mg/dl, and INR rose to 1.7. Then we decided to administer low doses of hydrocortisone. As a result of the treatment, bilirubin concentration was 14.61 mg/dl after 2 weeks. Finally all hepatic enzymes returned to normal values 5 months after stanozolol was discontinued. This treatment appears to be safe and leads to a more rapid reduction of bilirubin.

keywords:

Case reportSevere intrahepatic cholestasis and liver failure after stanozolol usage – case report and review of the literature

Piotr M. Stępień , Katarzyna Reczko , Anna Wieczorek , Dorota Zarębska-Michaluk , Paweł Pabjan , Teodora Król , Wiesław Kryczka

liver failure, stanozolol, anabolic steroids, hydrocortisone, cholestasis

Case report
Severe intrahepatic cholestasis and liver failure after stanozolol usage – case report and review of the literature

Piotr M. Stępień

,

Katarzyna Reczko

,

Anna Wieczorek

,

Dorota Zarębska-Michaluk

,

Paweł Pabjan

,

Teodora Król

,

Wiesław Kryczka