Significant reduction of peripheral blood interleukin-35 and CD4+EBI3+ T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients

Ouyang H, Xiang L, Chen J, Xu W, Jiao Y, Shen H. Significant reduction of peripheral blood interleukin-35 and CD4+EBI3+ T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients. Central European Journal of Immunology. 2017;42(1):91-96. doi:10.5114/ceji.2016.65892.

APA

Ouyang, H., Xiang, L., Chen, J., Xu, W., Jiao, Y.,  & Shen, H. (2017). Significant reduction of peripheral blood interleukin-35 and CD4+EBI3+ T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients. Central European Journal of Immunology, 42(1), 91-96. https://doi.org/10.5114/ceji.2016.65892

Chicago

Ouyang, Han, Li Xiang, Jianchang Chen, Weiting Xu, Yang Jiao,  and Huaying Shen. 2017. "Significant reduction of peripheral blood interleukin-35 and CD4+EBI3+ T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients". Central European Journal of Immunology 42 (1): 91-96. doi:10.5114/ceji.2016.65892.

Harvard

Ouyang, H., Xiang, L., Chen, J., Xu, W., Jiao, Y.,  and Shen, H. (2017). Significant reduction of peripheral blood interleukin-35 and CD4+EBI3+ T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients. Central European Journal of Immunology, 42(1), pp.91-96. https://doi.org/10.5114/ceji.2016.65892

MLA

Ouyang, Han et al. "Significant reduction of peripheral blood interleukin-35 and CD4+EBI3+ T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients." Central European Journal of Immunology, vol. 42, no. 1, 2017, pp. 91-96. doi:10.5114/ceji.2016.65892.

Vancouver

Ouyang H, Xiang L, Chen J, Xu W, Jiao Y, Shen H. Significant reduction of peripheral blood interleukin-35 and CD4+EBI3+ T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients. Central European Journal of Immunology. 2017;42(1):91-96. doi:10.5114/ceji.2016.65892.

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Introduction: Viral myocarditis (VMC) has become an increasingly common heart disease that endangers human health. In the present study, the plasma interleukin-35 (IL-35) level and the percentage of CD4⁺EBI3⁺ T cells in VMC patients were detected to investigate the significance of changes in these parameters in the plasma of VMC patients and their association with the disease.

Material and methods: ELISA was performed to detect the plasma IL-35 level and the percentage of peripheral blood CD4⁺EBI3⁺ T cells in 40 VMC patients and in 20 healthy individuals. Moreover, the plasma IL-17 levels in the VMC patients and in the healthy individuals were detected using an ELISA, and the cardiac Troponin-I (cTnI) levels were detected using a chemiluminescent microparticle immunoassay to compare the differences in the groups.

Results: Plasma IL-35 level and the percentage of CD4⁺EBI3⁺ T cells in acute phase VMC patients was lower than that in the healthy control group and the convalescent phase VMC patients. Additionally, the plasma IL-35 level in the VMC patients exhibited a negative correlation with the levels of cTnI and IL-17. The percentage of CD4⁺EBI3⁺ T cells also showed a negative correlation with the levels of cTnI and IL-17.

Conclusions: The plasma IL-35 level and the percentage of CD4⁺EBI3⁺ T cells in VMC patients was reduced, and the amount of the decrease was associated with the severity of the disease. These results suggest that IL-35 and CD4⁺EBI3⁺ T might play important roles in the progression of VMC and could be used as indictors of the disease.

keywords:

Significant reduction of peripheral blood interleukin-35 and CD4+EBI3+ T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients

Han Ouyang , Li Xiang , Jianchang Chen , Weiting Xu , Yang Jiao , Huaying Shen

viral disease, myocarditis, interleukin-35, EBI3

Han Ouyang

,

Li Xiang

,

Jianchang Chen

,

Weiting Xu

,

Yang Jiao

,

Huaying Shen