eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2020
vol. 45
 
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abstract:
Clinical immunology

Value of cord blood Treg population properties and function-associated characteristics for predicting allergy development in childhood

Viktor Černý
1
,
Petra Petrásková
1
,
Olga Novotná
1
,
Kristýna Boráková
2
,
Ludmila Prokešová
1
,
Libuše Kolářová
1
,
Jiří Hrdý
1

  1. Institute of Immunology and Microbiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic
  2. Institute for the Care of Mother and Child, Prague, Czech Republic
Centr Eur J Immunol 2020; 45 (4): 393-402
DOI: https://doi.org/10.5114/ceji.2020.103413
Online publish date: 2021/01/30
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Allergic diseases represent some of the most common immunological disorders with high clinical and economic impact. Despite intensive research, there are still few universally accepted and reliable biomarkers capable of predicting their development at an early age.

There is therefore a pressing need for identification of potential predictive factors and validation of their prognostic value by correlating them with allergy development.

Dysbalance of the branches of immune response, most often excessive Th2 polarization, is the principal cause of allergic diseases. Regulatory T cells (Treg) are a crucial population for the timely establishment of physiological immune polarization and induction and maintenance of tolerance against environmental antigens. This makes them a potentially promising candidate for an early marker predicting allergy development.

In our study, we analysed samples of cord blood of children of allergic mothers and children of healthy mothers by flow cytometry and retrospectively correlated the data with clinical allergy status of the children at the age of 6 to 10 years.

Studied parameters included cord blood Treg population proportions and functional properties – intracellular presence of IL-10 and TGF-, MFI of FoxP3. We observed higher percentage of Tregs in cord blood of children who did not develop allergy compared with allergic children. Further, we found higher numbers of IL-10+ Tregs in cord blood of healthy children of healthy mothers than in cord blood of children of allergic mothers and decreased TGF-+ cord blood Tregs in the group of allergic children of allergic mothers compared to all other groups.
keywords:

cord blood, Treg, regulatory T cells, allergy, TGF-, IL-10
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