lncRNA in HNSCC: challenges and potential

Kacper Guglas; Marta Bogaczyńska; Tomasz Kolenda; Marcel Ryś; Anna Teresiak; Renata Bliźniak; Izabela Łasińska; Jacek Mackiewicz; Katarzyna Lamperska

doi:10.5114/wo.2017.72382

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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4/2017
vol. 21

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abstract:

Review paper

lncRNA in HNSCC: challenges and potential

Kacper Guglas

,

Marta Bogaczyńska

,

Tomasz Kolenda

,

Marcel Ryś

,

Anna Teresiak

,

Renata Bliźniak

,

Izabela Łasińska

,

Jacek Mackiewicz

,

Katarzyna Lamperska

Contemp Oncol (Pozn) 2017; 21 (4): 259-266

DOI: https://doi.org/10.5114/wo.2017.72382

Online publish date: 2017/12/30

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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cause of cancer mortality in the world. Some progress has been made in the therapy of HNSCC, however treatment remains unsatisfactory. Recent studies have shown that different types of long non-coding RNAs (lncRNAs) are dysregulated in HNSCC and correlate with tumor progression, lymph node metastasis, clinical stage and poor prognosis. lncRNAs are a class of functional RNA molecules that can not be translated into proteins but can modulate the activity of transcription factors or regulate changes in chromatin structure. The lncRNAs might have potential of biomarker in HNSCC diagnosis, prognosis, prediction and targeted treatment. In this review we describe the potential role of lncRNAs as new biomarkers and discuss their features including source of origin, extraction methods, stability, detection methods and data normalization and potential function as biomarkers in HNSCC.

keywords:

lncRNA in HNSCC: challenges and potential

Kacper Guglas , Marta Bogaczyńska , Tomasz Kolenda , Marcel Ryś , Anna Teresiak , Renata Bliźniak , Izabela Łasińska , Jacek Mackiewicz , Katarzyna Lamperska

HNSCC, biomarkers, lncRNA, head and neck

Kacper Guglas

,

Marta Bogaczyńska

,

Tomasz Kolenda

,

Marcel Ryś

,

Anna Teresiak

,

Renata Bliźniak

,

Izabela Łasińska

,

Jacek Mackiewicz

,

Katarzyna Lamperska