<i>Gene profile in BRCA-negative breast cancer with the family history: a case report</i>

Agnieszka Kołacińska; Renata Kusińska; Maja Wasylecka-Morawiec; Zbigniew Morawiec

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

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1/2012
vol. 11

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abstract:

Case report

Gene profile in BRCA-negative breast cancer with the family history: a case report

Agnieszka Kołacińska

,

Renata Kusińska

,

Maja Wasylecka-Morawiec

,

Zbigniew Morawiec

Przegląd Menopauzalny 2012; 1: 14–18

Online publish date: 2012/02/29

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Hereditary breast cancer accounts for 4-10% of all cases; the majority of them are caused by BRCA1 and BRCA2 mutations. We report a case of a 29-year-old breast cancer patient, BRCA -negative, with the following family history: her mother was diagnosed with breast cancer at the age of 40 and her sister – with ovarian cancer at the age of 40. Her breast cancer tissue sample submitted was analyzed by MammaPrint, a 70-gene profile of breast cancer for the metastatic risk. The gene profile result showed high risk, which means that a lymph node-negative breast cancer patient has a 29% chance (95% CI 22-35) that her cancer will recur within 10 years without any adjuvant treatment.

keywords:

Gene profile in BRCA-negative breast cancer with the family history: a case report

Agnieszka Kołacińska , Renata Kusińska , Maja Wasylecka-Morawiec , Zbigniew Morawiec

breast cancer, BRCA , mutations

Agnieszka Kołacińska

,

Renata Kusińska

,

Maja Wasylecka-Morawiec

,

Zbigniew Morawiec