Original paper
Choosen inflammatory markers among patients with metabolic syndrome

Introduction: In XXI century more and more people suffers from overweight or obesity. Among patients with excessively developed fat tissue we may observed elevated levels of resisitin, tumour necrosis factor α (TNF-α) and high sensitivity C reactive protein (hsCRP). All those substances are strongly connected with subclinical inflammatory process. Values of hsCRP between 0.5-10 mg/dl are helpful to determined, mild, chronic, inflammatory state in human organism. Also levels of TNF- α are elevated in group of patient with obesity.

Aim: Estimation of concentration of soluble receptors for TNF- α (sTNFR1 and sTNFR2) and hsCRP in group of patients with metabolic syndrome (MS) and control group. Estimation of correlation between anthropometric parameters and chosen adipocytokines. Estimation of correlation between lipid parameters, TNF- α and hsCRP.

Material and methods: Eighty-five people with MS and 20 healthy volunteers were investigated. Anthropometrics parameters such as: waist and hips circumstance, body mass index (BMI), waist to hip ratio (WHR), high and weight were measured. Levels hsCRP were assessed using turbidimetric method and sTNFR1 and sTNFR2 using ELISA method.

Conclusions: In group of patients with MS, many metabolic disturbances were observed, such as: hyperglycemia, elevated levels of cholesterol LDL and triglycerides, low levels of HDL cholesterol. Higher concentration of soluble receptors for TNF-α were present in investigated group. Levels of hsCRP were elevated in population of patients with MS, with might be the proof of subclinical inflammatory process ongoing in this group. Blood serum concentration of hsCRP strongly correlates with levels of TNF-α . Choosen markers of inflammatory process such as sTNFR1 might correlates with lipids parameters – especially with triglycerides. That might connect chronic inflammatory state with process of development of atherosclerosis.