Postprandial sRAGE levels in type 1 diabetes mellitus in children and adolescents

Introduction. Hyperglycaemia state increases the accumulation of the advanced glycation end-products (AGEs) in the body, which, in turn, induce the development of micro – and macroangiopathic lesions through binding with their receptor, RAGE (Receptor for Advanced Glycation Endproducts). Soluble isoform of RAGE receptor (sRAGE), circulating in the serum, binds with AGEs, and inhibits their attachment to the surface receptor. In turn, the above mentioned interaction inhibits the activation of the surface receptor. Previous studies did not provide a clear answer to the question about the importance and role of sRAGE in the development and maintaining of inflammation in children and adolescents with type 1 diabetes mellitus (T1DM). Studies assessing the role of the above mentioned eproteins in postprandial period are scarce. Aim to compare sRAGE levels in T1DM children vs. the control group, and to assess sRAGE postprandial levels in T1DM children and adolescents. Material and methods. The study involved 71 patients (35 girls and 36 boys) aged 7–17 years, diagnosed with T1DM, with treatment duration from 6 to 60 months. The control group consisted of 20 children (9 girls and 11 boys) aged 6.5–16 years. Due to a potential impact on study results, patients with other diseases were excluded. sRAGE levels were measured in the morning on fasting (at blood glucose levels within 80–120mg% range), and also at 1, 2 and 4 hours after a standard meal. Results. In the T1DM group, statistically significant higher sRAGE levels were measured at 0’, 1 and 4h of the study compared to the control group. In the T1DM children with HbA1c level <8 % and diabetes mellitus duration <2 years, statistically significant higher sRAGE levels were observed on fasting, and at 1 and 4h of the study compared to the control group. In patients with T1DM, sRAGE fasting levels were statistically significanty higher compared to 1, 2 and 4h measurements. The results show a significant negative correlation between glucose and sRAGE levels measured at the 2nd hour of the study. However, no correlation between sRAGE and HbA1c levels as well as between diabetes mellitus duration were observed. Conclusions. The inflammation is more pronounced in the T1DM group and hyperglycaemia episodes increase inflammatory processes.