<br>Review article<br>Genetic factors in alcoholism

Jerzy Samochowiec

eISSN: 2084-9885
ISSN: 1896-6764

Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology

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2/2007
vol. 2

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abstract:

Review article
Genetic factors in alcoholism

Jerzy Samochowiec

Neuropsychiatria i Neuropsychologia 2007; 2, 2: 54–56

Online publish date: 2007/11/26

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It has been approximately estimated that 50-60% of individual differences in risk for alcoholism is genetic and this proportion is equal by man and woman. The main goal of this review article is to describe the current status of associations and linkage investigations in alcohol dependence studies. There are at least three approaches to identify important genes: first based on targeting genes on their importance in influencing alcohol sensitivity. The targeted gene can be overexpressed, undrexpressed or disrupted (gene knock-out). Second, one can seek genes that are important via their different expression. Third, one can seek gene variations that are associated with alcohol sensitivity. The first approach can be made only in animals. Each approach will be reviewed.

keywords:

Review articleGenetic factors in alcoholism

Jerzy Samochowiec

alcoholism, typology, association studies, genetics

Review article
Genetic factors in alcoholism