eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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2/2011
vol. 36
 
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abstract:

Review paper
Immunostimulatory effects of lipopolysaccharide

Marek P. Dąbrowski
,
Wanda Stankiewicz

(Centr Eur J Immunol 2011; 36 (2): 85-86)
Online publish date: 2011/06/20
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The lectin mitogens Con A and PHA administered in vitro stimulate preferentially proliferative response of T lymphocytes. The response is accepted as a reflective for feature of immune competence of responding cells. The accessibility of specific phytomitogens for experimental determination of T lymphocyte properties creates a comfortable investigative circumstances. The authors explain why the nature of the population of B lymphocytes excludes the existence of a similar specific universal experimental tool, which could reveal complex immune properties of the population. The mechanisms of in vitro influence of putative candidates for being the B cell mitogens (PWM, LPS) are shortly presented and discussed. On the grounds of these data authors suggest that no PWM nor LPS can be estimated as a specific and selective mitogens for B lymphocytes.
keywords:

LPS, why specific B cell mitogen does not exists?
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