eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
2/2011
vol. 36
 
Share:
Send email
Share:
abstract:

Review paper
RLR receptors – important elements of innate immunity

Joanna Śliwa-Dominiak
,
Wiesław Deptuła

(Centr Eur J Immunol 2011; 36 (2): 117-119)
Online publish date: 2011/06/20
View full text Get citation
 
The paper presents the RLRs (RIG-I-like receptors) that are members of PRRs (pathogen recognition receptors) and are found on immunity system cells, binding to structures originating from germs, called as PAMP (pathogen-associated molecular patterns). PRRs are divided on secreted receptors, surface receptors engaged in phagocytosis and cell activating receptors or receptors expressed on immunity and other cells surface. RLRs belong to the third group of PRRs. Among RLRs there are RIG-I receptor (cytosolic double-stranded RNA helicases retinoic-acid-inducible gene I) i MDA5 receptor (melanoma differentiation-associated gene 5). Both RIG-I and MDA5 play a major role in recognition of RNA viruses in DCs, macrophages and fibroblasts. There has been shown that RIG-I binds 5’-triphosphorylated ssRNA and short dsRNA viruses whereas MDA5 preferentially recognizes longer-dsRNA. RLRs are receptors of innate immunity, that are very important in antiviral response. It seems that those receptors determine significant defense line in viral infection and restrict replication and invasion of pathogens.
keywords:

innate immunity, immunological response, receptors, RIG-I, MDA5, viruses
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.