A case report of glioma with cerebral hemorrhage as the first symptom

Tao Xie; Xue-Xin He; Qian Sun; Zhuo-Feng Mao; Xiao-Peng Wang

doi:10.5114/fn.2024.145177

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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abstract:

Case report

A case report of glioma with cerebral hemorrhage as the first symptom

Tao Xie

¹

,

Xue-Xin He

²

,

Qian Sun

¹

,

Zhuo-Feng Mao

¹

,

Xiao-Peng Wang

¹

Department of Neurology, The Second Hospital of Hebei Medical University, China
Department of Rehabilitation, The Traditional Chinese Medical Hospital of Shijiazhuang, China

Folia Neuropathol 2024; 62 (4)

DOI: https://doi.org/10.5114/fn.2024.145177

Online publish date: 2024/12/02

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Introduction:
High-grade gliomas are the most common and most lethal primary cancers of the central nervous system. Glioma patients with initial symptoms of cerebral hemorrhage are prone to clinical misdiagnosis and delayed diagnosis.

Case summary:
This paper reports the clinical data of a 40-year-old man with glioma who initially presented with cerebral hemorrhage. Cerebral computed tomography (CT) revealed left parietal cerebral hemorrhage, while contrast-enhanced magnetic resonance imaging (MRI) revealed abnormal enhancement of the left frontoparietal junction, indicating internal bleeding of metastatic tumor. Pathological examination confirmed a high-grade glioma, with immunohistochemistry indicating positive glial fibrillary acidic protein (GFAP) and 40% Ki-67 positive labeling. Consequently, the patient received a final diagnosis of glioma (WHO grade IV).

Conclusions:
We report an interesting case in which glioma initially presented with cerebral hemorrhage. Therefore, gliomas should be considered as a possible cause of cerebral hemorrhage in patients without risk factors for hemorrhage.

keywords:

A case report of glioma with cerebral hemorrhage as the first symptom

Tao Xie 1 , Xue-Xin He 2 , Qian Sun 1 , Zhuo-Feng Mao 1 , Xiao-Peng Wang 1

cerebral hemorrhage, glial fibrillary acidic protein (GFAP), clinical misdiagnosis, glioma

Tao Xie

¹

,

Xue-Xin He

²

,

Qian Sun

¹

,

Zhuo-Feng Mao

¹

,

Xiao-Peng Wang

¹