A new implant device to prevent edema-associated underdosage in high-dose-rate interstitial brachytherapy of mobile tongue cancer

Ken Yoshida; Tadayuki Kotsuma; Hironori Akiyama; Hideya Yamazaki; Tadashi Takenaka; Koji Masui; Yutaka Tsujimoto; Naoya Murakami; Yasuo Uesugi; Taiju Shimbo; Nobuhiko Yoshikawa; Hiroto Yoshioka; Mio Nakata; Takumi Arika; Yuji Takaoka; Eiichi Tanaka; Nikolaos Tselis

doi:10.5114/jcb.2019.91225

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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abstract:

Case report

A new implant device to prevent edema-associated underdosage in high-dose-rate interstitial brachytherapy of mobile tongue cancer

Ken Yoshida

¹

,

Tadayuki Kotsuma

²

,

Hironori Akiyama

³

,

Hideya Yamazaki

⁴

,

Tadashi Takenaka

⁴

,

Koji Masui

⁴

,

Yutaka Tsujimoto

⁵

,

Naoya Murakami

⁶

,

Yasuo Uesugi

⁷

,

Taiju Shimbo

¹

,

Nobuhiko Yoshikawa

¹

,

Hiroto Yoshioka

¹

,

Mio Nakata

¹

,

Takumi Arika

⁸

,

Yuji Takaoka

²

,

Eiichi Tanaka

²

,

Nikolaos Tselis

⁹

Department of Radiation Oncology, Osaka Medical College, Takatsuki, Osaka, Japan
Department of Radiation Oncology, National Hospital Organization Osaka National Hospital, Osaka, Japan
Department of Oral Radiology, Osaka Dental University, Osaka, Japan
Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
Department of Radiology, National Hospital Organization Osaka National Hospital, Osaka, Japan
Department of Radiation Oncology, National Cancer Center Hospital, Japan
Department of Rehabilitation Sciences, Faculty of Allied Health Sciences, Kansai University of Welfare Sciences, Japan
Department of Oral Surgery, National Hospital Organization Osaka National Hospital, Osaka, Japan
Department of Radiation Oncology, Johann Wolfgang Goethe University Frankfurt, Germany

J Contemp Brachytherapy 2019; 11, 6: 573–578

DOI: https://doi.org/10.5114/jcb.2019.91225

Online publish date: 2019/12/25

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AMA

Yoshida K, Kotsuma T, Akiyama H, et al. A new implant device to prevent edema-associated underdosage in high-dose-rate interstitial brachytherapy of mobile tongue cancer. Journal of Contemporary Brachytherapy. 2019;11(6):573-578. doi:10.5114/jcb.2019.91225.

APA

Yoshida, K., Kotsuma, T., Akiyama, H., Yamazaki, H., Takenaka, T.,  & Masui, K. et al. (2019). A new implant device to prevent edema-associated underdosage in high-dose-rate interstitial brachytherapy of mobile tongue cancer. Journal of Contemporary Brachytherapy, 11(6), 573-578. https://doi.org/10.5114/jcb.2019.91225

Chicago

Yoshida, Ken, Tadayuki Kotsuma, Hironori Akiyama, Hideya Yamazaki, Tadashi Takenaka, Koji Masui,  and Yutaka Tsujimoto et al. 2019. "A new implant device to prevent edema-associated underdosage in high-dose-rate interstitial brachytherapy of mobile tongue cancer". Journal of Contemporary Brachytherapy 11 (6): 573-578. doi:10.5114/jcb.2019.91225.

Harvard

Yoshida, K., Kotsuma, T., Akiyama, H., Yamazaki, H., Takenaka, T., Masui, K., Tsujimoto, Y., Murakami, N., Uesugi, Y., Shimbo, T., Yoshikawa, N., Yoshioka, H., Nakata, M., Arika, T., Takaoka, Y., Tanaka, E.,  and Tselis, N. (2019). A new implant device to prevent edema-associated underdosage in high-dose-rate interstitial brachytherapy of mobile tongue cancer. Journal of Contemporary Brachytherapy, 11(6), pp.573-578. https://doi.org/10.5114/jcb.2019.91225

MLA

Yoshida, Ken et al. "A new implant device to prevent edema-associated underdosage in high-dose-rate interstitial brachytherapy of mobile tongue cancer." Journal of Contemporary Brachytherapy, vol. 11, no. 6, 2019, pp. 573-578. doi:10.5114/jcb.2019.91225.

Vancouver

Yoshida K, Kotsuma T, Akiyama H, Yamazaki H, Takenaka T, Masui K et al. A new implant device to prevent edema-associated underdosage in high-dose-rate interstitial brachytherapy of mobile tongue cancer. Journal of Contemporary Brachytherapy. 2019;11(6):573-578. doi:10.5114/jcb.2019.91225.

Purpose
Tongue edema is a potential cause of treatment target underdosage in high-dose-rate interstitial brachytherapy (HDR-ISBT) of mobile tongue cancer. To prevent such edema-associated alteration of dosimetry, we developed a special silicon device. In this report we communicate our initial experience with two mobile tongue cancer patients whom we treated using this new device.

Material and methods
The device consists of silicone tubes with a fixed width and scalable length depending on tongue size. These tubes are lined and fixed like a palisade, allowing the device to be used also as a template. The device is placed next to the lateral border of the tongue and on the floor of the mouth. In addition, a vinyl template can be placed on the dorsal tongue surface with both devices combined for implantation guidance. Between June and August 2012, two patients with locally confined tongue cancer were treated.

Results
Between June and August 2012, two mobile tongue cancer patients classified as cT2N0M0 were treated with HDR-ISBT using the silicone device. They underwent ISBT as monotherapy with fractional doses of 6.0 Gy up to a total physical dose of 54.0 Gy. The D₉₀ (CTV) values of both patients were 6.3 Gy and 6.6 Gy and the D_2cc (mandible) values were 3.4 Gy and 2.6 Gy, respectively. At present, both patients remain without local disease recurrence at 60 and 56 months after ISBT, respectively.

Conclusions
The described silicone device has the potential to prevent underdosage to the treatment target related to tongue edema. It has been shown to be safe and easy to implement.

keywords:

A new implant device to prevent edema-associated underdosage in high-dose-rate interstitial brachytherapy of mobile tongue cancer

tongue edema, silicone device, high-dose-rate interstitial brachytherapy, mobile tongue cancer