A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case

Szpecht D, Skalska-Sadowska J, Michniewicz B, et al. A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case. Central European Journal of Immunology. 2018;43(3):346-352. doi:10.5114/ceji.2018.80056.

APA

Szpecht, D., Skalska-Sadowska, J., Michniewicz, B., Gadzinowski, J., Machowska, L.,  & Pieczonka, A. et al. (2018). A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case. Central European Journal of Immunology, 43(3), 346-352. https://doi.org/10.5114/ceji.2018.80056

Chicago

Szpecht, Dawid, Jolanta Skalska-Sadowska, Barbara Michniewicz, Janusz Gadzinowski, Ludmiła Machowska, Anna Pieczonka,  and Anna Przybyłowicz-Chalecka et al. 2018. "A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case". Central European Journal of Immunology 43 (3): 346-352. doi:10.5114/ceji.2018.80056.

Harvard

Szpecht, D., Skalska-Sadowska, J., Michniewicz, B., Gadzinowski, J., Machowska, L., Pieczonka, A., Przybyłowicz-Chalecka, A., Kanduła, Z., Jarmuż-Szymczak, M., Lewandowski, K.,  and Wachowiak, J. (2018). A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case. Central European Journal of Immunology, 43(3), pp.346-352. https://doi.org/10.5114/ceji.2018.80056

MLA

Szpecht, Dawid et al. "A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case." Central European Journal of Immunology, vol. 43, no. 3, 2018, pp. 346-352. doi:10.5114/ceji.2018.80056.

Vancouver

Szpecht D, Skalska-Sadowska J, Michniewicz B, Gadzinowski J, Machowska L, Pieczonka A et al. A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case. Central European Journal of Immunology. 2018;43(3):346-352. doi:10.5114/ceji.2018.80056.

PlumX metrics:

Neonatal congenital leukemia (CL) constitutes less than 1% of all childhood leukemia cases and is diagnosed in 1 to 5 per million live births. In the neonatal period acute myeloid leukemia (AML) is described in 56-64% of cases, acute lymphoblastic leukemia (ALL) in 21-38% of cases and mixed-phenotype acute leukemia (MPAL) in less than 5% of cases. Rearrangements of the mixed-lineage leukemia (KMT2A alias MLL) gene are found in > 70% of infant leukemia cases. The incidence of the most frequent KMT2A rearrangements in newborns with congenital MPAL is unknown. We report a male term newborn with “blueberry muffin” syndrome, which had been noted at birth, as a presenting sign of acute leukemia. Eight-color multiparameter flow cytometry showed a blast population corresponding to a myeloid lineage with monocytic differentiation positive for CD33+/CD15+/CD11c+/CD64+/HLA-DR+/CD4+, negative for MPO–/CD34–/CD19–/CD79a–/CD117–/CD13–/CD14–/CD36–/cCD3–/CD2–/CD7–, and additionally positive for sCD3 (40%). Mixed-phenotype acute leukemia according to the World Health Organization (WHO) classification was diagnosed with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearrangement. The patient had an unfavorable response to chemotherapy and died on the 5th day of life.

keywords:

A newborn with congenital mixed phenotype acute leukemia with complex translocation t(10;11)(p12;q23) with KMT2A/MLLT10 rearranged – a report of an extremely rare case

Dawid Szpecht , Jolanta Skalska-Sadowska , Barbara Michniewicz , Janusz Gadzinowski , Ludmiła Machowska , Anna Pieczonka , Anna Przybyłowicz-Chalecka , Zuzanna Kanduła , Małgorzata Jarmuż-Szymczak , Krzysztof Lewandowski , Jacek Wachowiak

newborn, congenital leukemia, mixed phenotype acute leukemia

Dawid Szpecht

,

Jolanta Skalska-Sadowska

,

Barbara Michniewicz

,

Janusz Gadzinowski

,

Ludmiła Machowska

,

Anna Pieczonka

,

Anna Przybyłowicz-Chalecka

,

Zuzanna Kanduła

,

Małgorzata Jarmuż-Szymczak

,

Krzysztof Lewandowski

,

Jacek Wachowiak