A prognostic significance of surgical margin in head and neck cancer

Krzysztof Szyfter; Daniela Mielcarek-Kuchta; Katarzyna Kiwerska

eISSN: 2084-9842
ISSN: 1643-9279

Postępy w chirurgii głowy i szyi/Advances in Head and Neck Surgery

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3/2009
vol. 8

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abstract:

A prognostic significance of surgical margin in head and neck cancer

Krzysztof Szyfter

,

Daniela Mielcarek-Kuchta

,

Katarzyna Kiwerska

Postępy w chirurgii głowy i szyi 2009; 3: 56–62

Online publish date: 2010/01/04

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Failure of the treatment in head and neck cancer is connected with local and distal tumor metastases, local recurrence and formation of second primary tumors. Clinical procedures have a limited applicability to a prediction a further progression of the tumor. Hence an attention has turned towards molecular and subcellular analyses. It is not clear yet, which of the analyses would provide a better prognostic information, that in primary tumor itself or in the histologically normal surgical margin. An informative potential of the analysis of TP53 gene mutations, hypermethylation of promoters of the chosen genes and instability of microsatellite sequences for disease prognosis is reviewed. While TP53 mutation profile and gene expression appear to be the most reliable prognostic factors, the limitations of using the molecular techniques are discussed.

keywords:

A prognostic significance of surgical margin in head and neck cancer

Krzysztof Szyfter , Daniela Mielcarek-Kuchta , Katarzyna Kiwerska

head and neck cancer, disease prognosis, molecular analysis, surgical margin, molecular analyses, gene TP53

Krzysztof Szyfter

,

Daniela Mielcarek-Kuchta

,

Katarzyna Kiwerska