Acute-on-chronic hepatitis. A case report of autoimmune hepatitis/primary sclerosing cholangitis/ulcerative colitis overlap syndrome in a 15-year-old patient

Aneta Nalepa; Małgorzata Woźniak; Joanna Cielecka-Kuszyk; Marek Stefanowicz; Irena Jankowska; Maciej Dądalski; Joanna Pawłowska

doi:10.5114/ceh.2017.65501

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Case report

Acute-on-chronic hepatitis. A case report of autoimmune hepatitis/primary sclerosing cholangitis/ulcerative colitis overlap syndrome in a 15-year-old patient

Aneta Nalepa

,

Małgorzata Woźniak

,

Joanna Cielecka-Kuszyk

,

Marek Stefanowicz

,

Irena Jankowska

,

Maciej Dądalski

,

Joanna Pawłowska

Clin Exp HEPATOL 2017; 3, 1: 28–32

DOI: https://doi.org/10.5114/ceh.2017.65501

Online publish date: 2017/01/30

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AMA

Nalepa A, Woźniak M, Cielecka-Kuszyk J, et al. Acute-on-chronic hepatitis. A case report of autoimmune hepatitis/primary sclerosing cholangitis/ulcerative colitis overlap syndrome in a 15-year-old patient. Clinical and Experimental Hepatology. 2017;3(1):28-32. doi:10.5114/ceh.2017.65501.

APA

Nalepa, A., Woźniak, M., Cielecka-Kuszyk, J., Stefanowicz, M., Jankowska, I.,  & Dądalski, M. et al. (2017). Acute-on-chronic hepatitis. A case report of autoimmune hepatitis/primary sclerosing cholangitis/ulcerative colitis overlap syndrome in a 15-year-old patient. Clinical and Experimental Hepatology, 3(1), 28-32. https://doi.org/10.5114/ceh.2017.65501

Chicago

Nalepa, Aneta, Małgorzata Woźniak, Joanna Cielecka-Kuszyk, Marek Stefanowicz, Irena Jankowska, Maciej Dądalski,  and Joanna Pawłowska. 2017. "Acute-on-chronic hepatitis. A case report of autoimmune hepatitis/primary sclerosing cholangitis/ulcerative colitis overlap syndrome in a 15-year-old patient". Clinical and Experimental Hepatology 3 (1): 28-32. doi:10.5114/ceh.2017.65501.

Harvard

Nalepa, A., Woźniak, M., Cielecka-Kuszyk, J., Stefanowicz, M., Jankowska, I., Dądalski, M.,  and Pawłowska, J. (2017). Acute-on-chronic hepatitis. A case report of autoimmune hepatitis/primary sclerosing cholangitis/ulcerative colitis overlap syndrome in a 15-year-old patient. Clinical and Experimental Hepatology, 3(1), pp.28-32. https://doi.org/10.5114/ceh.2017.65501

MLA

Nalepa, Aneta et al. "Acute-on-chronic hepatitis. A case report of autoimmune hepatitis/primary sclerosing cholangitis/ulcerative colitis overlap syndrome in a 15-year-old patient." Clinical and Experimental Hepatology, vol. 3, no. 1, 2017, pp. 28-32. doi:10.5114/ceh.2017.65501.

Vancouver

Nalepa A, Woźniak M, Cielecka-Kuszyk J, Stefanowicz M, Jankowska I, Dądalski M et al. Acute-on-chronic hepatitis. A case report of autoimmune hepatitis/primary sclerosing cholangitis/ulcerative colitis overlap syndrome in a 15-year-old patient. Clinical and Experimental Hepatology. 2017;3(1):28-32. doi:10.5114/ceh.2017.65501.

PlumX metrics:

Acute-on-chronic liver failure (ACLF) is a disease in which a rapid deterioration of liver function occurs in patients with chronic liver disease, and is usually associated with a precipitating event. We present the case of a boy with autoimmune hepatitis/primary sclerosing cholangitis/ulcerative colitis (AIH/PSC/UC) overlap syndrome, in whom liver function was stable for 4.5 years of treatment. At 15 years of age the patient was hospitalized due to a deterioration of his general condition, severe abdominal pain, diarrhoea, vomiting and weight loss. There was also a rapid deterioration of liver function and a deterioration of renal function. Despite a wide spectrum of diagnostic examinations, no precipitating agent was found. After two episodes of massive bleeding from the gastrointestinal tract, the patient was transferred to the intensive care unit. The patient underwent a successful liver transplantation. ACLF can cause irreversible liver failure with a high mortality rate, which calls for liver transplantation.

keywords:

Acute-on-chronic hepatitis. A case report of autoimmune hepatitis/primary sclerosing cholangitis/ulcerative colitis overlap syndrome in a 15-year-old patient

Aneta Nalepa , Małgorzata Woźniak , Joanna Cielecka-Kuszyk , Marek Stefanowicz , Irena Jankowska , Maciej Dądalski , Joanna Pawłowska

children, liver transplantation, ACLF

Aneta Nalepa

,

Małgorzata Woźniak

,

Joanna Cielecka-Kuszyk

,

Marek Stefanowicz

,

Irena Jankowska

,

Maciej Dądalski

,

Joanna Pawłowska