eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
4/2022
vol. 47
 
Share:
Send email
Share:
abstract:
Clinical immunology

AgNOR patterns and configurations in adult acute leukemia patients

Małgorzata Gajewska
1
,
Iwona Kwiecień
2
,
Elżbieta Rutkowska
2
,
Piotr Rzepecki
1
,
Kazimierz Sułek
1

  1. Department of Internal Medicine and Hematology, Military Institute of Medicine, Warsaw
  2. Laboratory of Hematology and Flow Cytometry, Department of Internal Medicine and Hematology, Military Institute of Medicine, Warsaw, Poland
Cent Eur J Immunol 2022; 47 (4): 323-331
DOI: https://doi.org/10.5114/ceji.2022.124252
Online publish date: 2023/01/31
View full text Get citation
 
PlumX metrics:
The number of argyrophilic nucleolus organizer regions (AgNOR) is related to the proliferative activity of cells and the degree of neoplastic transformation. The surface area of AgNOR depending on nuclear structure may be a predictor of tumor recurrence, while research into acute leukemias is scarce. The aim of the study was to determine whether the assessment of AgNOR parameters is useful in the differentiation of acute leukemias and, together with cytogenetic changes, would allow for a quick evaluation of the risk group. The AgNOR structures were analyzed in terms of the shape, surface area and distribution in bone marrow blast cells in patients with acute leukemias. We observed significant differences in the AgNOR structures, simple, compound and complex patterns between acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Complex structures were more numerous in ALL than in AML patients. There were significant differences in the distribution of AgNOR configuration among various cytogenetic AML risk groups. We observed a significant difference in the mean number of AgNOR between ALL-T and ALL-B. We detected diversity in the AgNOR structures and pattern map in AML and ALL. Thus, presentation of a variety of AgNOR configurations is innovative and can be a useful method of differentiating patients with acute leukemia types and cytogenetic risk.
keywords:

bone marrow, acute leukemia, argyrophilic nucleolar organizer regions, blasts, Ag-NOR patterns
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.