Alpha-synuclein decreases arachidonic acid incorporation into rat striatal synaptoneurosomes

Agata Adamczyk; Maria Kacprzak; Anna Kaźmierczak

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

4/2007
vol. 45

Send email

Copy url:

abstract:

Alpha-synuclein decreases arachidonic acid incorporation into rat striatal synaptoneurosomes

Agata Adamczyk

,

Maria Kacprzak

,

Anna Kaźmierczak

Folia Neuropathol 2007; 45 (4): 230-235

Online publish date: 2007/12/21

View full text Get citation

In the present study we investigated the role of alpha-synuclein (ASN) and its fragment NAC in arachidonic acid (AA) turnover in the rat brain. Our data indicated that ASN (10 µM) inhibited [3H]AA incorporation into phosphatidylethanolamine (PE), phosphatidylcholine (PC) and phosphatidylserine (PS) together with phosphatidic acid (PA) by 13%, 27% and 38%, respectively. NAC (10 µM) reduced [3H]AA incorporation into PC and PA + PS by 17% and 34%, respectively. Because ASN and NAC lower the level of AA-CoA we suggest that inhibition of AA-CoA synthase is responsible for disturbed [3H]AA incorporation. In conclusion, ASN and NAC modulate phospholipid compositions in plasma membranes and affect synaptic endings function.

keywords:

Alpha-synuclein decreases arachidonic acid incorporation into rat striatal synaptoneurosomes

Agata Adamczyk , Maria Kacprzak , Anna Kaźmierczak

striatum, alpha-synuclein, non-amyloid beta component of Alzheimer’s disease amyloid, arachidonic acid

Agata Adamczyk

,

Maria Kacprzak

,

Anna Kaźmierczak