Alterations in innate antibacterial response after immunomodulating nutrition

Robert Słotwiński; Sylwia M. Słotwińska; Sylwia Kędziora; Barbara J. Bałan

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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5/2009
vol. 4

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abstract:

Review paper

Alterations in innate antibacterial response after immunomodulating nutrition

Robert Słotwiński

,

Sylwia M. Słotwińska

,

Sylwia Kędziora

,

Barbara J. Bałan

Przegląd Gastroenterologiczny 2009; 4 (5): 231–237

Online publish date: 2009/11/09

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The immune disorders occurring together with the surgical injury as well as the malnutrition which worsens after major surgery usually worsens outcome. Septic infections in malnourished surgical patients show the highest morbidity and mortality rate. The attempt to correct the postoperative immune and nutritional disorders by introducing immunomodulating nutrition is a promising way of improving outcome, but as yet little is known about the mechanisms of correcting postoperative extensive inflammatory response (SIRS) to a massive infection using this type of nutrition. A significant role in innate antibacterial and inflammatory response play Toll-like receptors that recognize PAMPs-pathogen-associated molecular patterns. In this paper special emphasis was put on clinical trials and the research result for TLR-dependent immune response, anti-bacterial/anti-inflammatory response applying immunonutrition with increased concentrations of glutamine and unsaturated fatty acids.

keywords:

Alterations in innate antibacterial response after immunomodulating nutrition

Robert Słotwiński , Sylwia M. Słotwińska , Sylwia Kędziora , Barbara J. Bałan

innate immunity, immunonutrition, toll-like receptors, sepsis

Robert Słotwiński

,

Sylwia M. Słotwińska

,

Sylwia Kędziora

,

Barbara J. Bałan