Amyloid pathology in the brain after ischemia

Ryszard Pluta; Marzena Ułamek-Kozioł; Sławomir Januszewski; Stanisław Czuczwar

doi:10.5114/fn.2019.88450

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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3/2019
vol. 57

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abstract:

Review paper

Amyloid pathology in the brain after ischemia

Ryszard Pluta

¹

,

Marzena Ułamek-Kozioł

^{1, 2}

,

Sławomir Januszewski

¹

,

Stanisław J. Czuczwar

³

Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
Department of Pathophysiology, Medical University of Lublin, Lublin, Poland

Folia Neuropathol 2019; 57 (3): 220-226

DOI: https://doi.org/10.5114/fn.2019.88450

Online publish date: 2019/09/30

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As the population is aging all over the world, the economic burden of ischemic brain injuries is constantly increasing. Human brain ischemia is one of the leading causes of premature death, significant morbidity and physical and mental disabilities, resulting in a lower quality of life and unusually high costs of health and social care. One of the most difficult problems associated with the pathology of the brain after ischemia is progressive dementia observed in people who survived the stroke. More recently, brain ischemia has been shown to elicit Alzheimer’s disease neuropathologic change, possibly facilitating the development of dementia due to the amyloidogenic processing of Alzheimer’s disease-related amyloid protein precursor into amyloid. The main purpose of this review is to present the development of Alzheimer’s disease neuropathologic change in the brain after human and experimental ischemia, with a particular emphasis on proteins and genes involved in the amyloidogenic processing of the amyloid protein precursor to amyloid.

keywords:

brain ischemia, ischemic stroke, amyloid protein precursor, amyloid, β-secretase, presenilin 1, presenilin 2, cognitive decline, dementia, protein, gene

Amyloid pathology in the brain after ischemia

Ryszard Pluta 1 , Marzena Ułamek-Kozioł 1, 2 , Sławomir Januszewski 1 , Stanisław J. Czuczwar 3

brain ischemia, ischemic stroke, amyloid protein precursor, amyloid, β-secretase, presenilin 1, presenilin 2, cognitive decline, dementia, protein, gene

Ryszard Pluta

¹

,

Marzena Ułamek-Kozioł

^{1, 2}

,

Sławomir Januszewski

¹

,

Stanisław J. Czuczwar

³