Analysis of microsatellite instability markers in women with endometrial cancer

Andrzej Kulig; Beata Smolarz; Grażyna Dec; Hanna Romanowicz-Makowska

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

5/2004
vol. 3

Send email

Copy url:

abstract:

Analysis of microsatellite instability markers in women with endometrial cancer

Andrzej Kulig

,

Beata Smolarz

,

Grażyna Dec

,

Hanna Romanowicz-Makowska

Prz Menopauz 2004; 5: 14-18

Online publish date: 2004/10/28

View full text Get citation

Purpose: Microsatellite instability (MSI) play important role for the development of endometrial cancer. The aim of this study was evaluation of microsatellite instability in 10 postmenopausal women with endometrial cancer.
Materials and methods: Cancer tissue and blood were obtained from the same patients. Blood samples from age matched healthy women served as control (n=25). MSI was studied at five loci containing single- or dinucleotide repeat sequences and mapping to different chromosomal locations: BAT-25 (at locus 4q12), BAT-26 (2p16), D2S123 (2p16-p21), D5S346 (5q21-q22) and D17S250 (17q11.2-q12).
Results and conlusion: No differences in the MSI frequencies between blood and cancer tissue obtained from patients were detected. The microsatellite instability status was significantly higher in endometrial cancer tissue [4/10 (40%) ] compared as control [3/25 (12%)] (p<0.05).
The results suggest that the microsatellite instability seems to be important in the development sporadic endometrial cancer.

keywords:

Analysis of microsatellite instability markers in women with endometrial cancer

Andrzej Kulig , Beata Smolarz , Grażyna Dec , Hanna Romanowicz-Makowska

endometrial cancer, microsatellite instability markers, PCR

Andrzej Kulig

,

Beata Smolarz

,

Grażyna Dec

,

Hanna Romanowicz-Makowska