Angiomodulatory properties of some antibiotics and Tołpa Peat Preparation

Dorota M. Radomska-Leśniewska; Ewa Skopińska-Różewska; Jarosław Jóźwiak; Urszula Demkow; Barbara Joanna Bałan

doi:10.5114/ceji.2016.58312

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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1/2016
vol. 41

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abstract:

Experimental immunology

Angiomodulatory properties of some antibiotics and Tołpa Peat Preparation

Dorota M. Radomska-Leśniewska

,

Ewa Skopińska-Różewska

,

Jarosław Jóźwiak

,

Urszula Demkow

,

Barbara Joanna Bałan

(Cent Eur J Immunol 2016; 41 (1): 19-24)

DOI: https://doi.org/10.5114/ceji.2016.58312

Online publish date: 2016/03/24

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Deterioration of the immune system due to antibiotic therapy can be restored by immunomodulator application. In this paper we estimate the effect of ampicillin, amikacin, doxycycline, rifampicin, rifamycine and immunomodulator Tołpa Peat Preparation (TPP) on neovascular reaction induced in murine skin by human mononuclear cells (MNC) injection. MNC originating from 15 healthy volunteers were injected intradermally to Balb/c mice. Antibiotics (3, 15, or 75 mg/kg of body weight) alone or with TPP (10 mg/kg of body weight) were administrated subcutaneously to mice on three consecutive days. The number of newly formed blood vessels was measured in dissection microscope 72 hours after cell injection. Results: TPP stimulated angiogenic activity of MNC at the dose 5 and 10 mg/kg. Rifamycine exerted strong stimulatory action, ampicillin slightly stimulated immune response, while doxycycline and rifampicin downregulated it. Amikacin did not influence the results of angiogenesis tests. Studied antibiotics (15 mg/kg), except rifamycine, inhibit the angiostimulatory effect of the tested immunomodulator. TPP should be applied after antibiotic therapy to maintain its stimulatory effect and restore proper host immune function.

keywords:

Angiomodulatory properties of some antibiotics and Tołpa Peat Preparation

Dorota M. Radomska-Leśniewska , Ewa Skopińska-Różewska , Jarosław Jóźwiak , Urszula Demkow , Barbara Joanna Bałan

antibiotics, angiogenesis, Tołpa Peat Preparation (TPP), amikacin, ampicillin, doxycycline, rifamycine, rifampicin, immune system

Dorota M. Radomska-Leśniewska

,

Ewa Skopińska-Różewska

,

Jarosław Jóźwiak

,

Urszula Demkow

,

Barbara Joanna Bałan