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Alergologia Polska - Polish Journal of Allergology
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2/2024
vol. 11
 
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abstract:
Original paper

Antibody response against an inactive SARS-CoV-2 vaccine among healthcare workers occupied in different divisions

Feridun Gürlek
1
,
Eyyüp Taşdemir
2
,
Fatih Coşkun
2
,
Ayşe Ulusoy Karaca
3
,
Taşkın Erkinüresin
4
,
Öner Özdemir
5

  1. Department of Allergy and Immunology, University of Health Sciences, Bursa Training and Research Hospital, Bursa, Türkiye
  2. Department of Internal Medicine, University of Health Sciences, Bursa Training and Research Hospital, Bursa, Türkiye
  3. Department of Microbiology, University of Health Sciences, Bursa Training and Research Hospital, Bursa, Türkiye
  4. Department of Pathology, University of Health Sciences, Bursa Training and Research Hospital, Bursa, Türkiye
  5. Department of Paediatric Allergy and Immunology, Sakarya Training and Research Hospital, Sakarya, Türkiye
Alergologia Polska – Polish Journal of Allergology 2024; 11, 2: 128–133
DOI: https://doi.org/10.5114/pja.2024.140250
Online publish date: 2024/06/04
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Aim:
The aim of the article was to examine the relationship between healthcare workers’ (HCW) antibody responses to the inactivated SARS-CoV-2 vaccine and the division in which they are employed.

Material and methods:
Study data were obtained retrospectively from hospital medical records. 90.8% of participants (n = 177) who had received 2 doses of the inactivated SARS-CoV-2 vaccine but who had not had COVID-19 disease before and whose polymerase chain reaction (PCR) test positivity was not detected, without acquired or primary immunodeficiency and not using immunosuppressive drugs, and tested for SARS-CoV-2 antibodies between 7 and 14 days after the second dose of the vaccine, were included in our study. The control group consisted of 9.2% (n = 18) unvaccinated individuals with the same characteristics.

Results:
The study included 177 people who received 2 doses of the inactivated SARS-CoV-2 vaccine and 18 people who had never been vaccinated, for a total of 195 HCWs. When the SARS-CoV-2 antibody test results of the participants were examined, it was found that 6.2% (n = 12) of the antibody level was negative, 24.1% (n = 47) was positive with a low antibody response between 1 and 10, and 69.7% (n = 136) was positive with a high antibody response. There was no statistically significant difference (p > 0.05) observed in the antibody level results of HCWs who received the SARS-CoV-2 vaccination. Among HCWs who had received vaccinations, the rate of SARS-CoV-2 IgG negativity was 2/177 (1%) and the rate of seroconversion was 175/177 (99%).

Conclusions:
The SARS-CoV-2 IgG negativity rate was 1% and the seroconversion rate was 99% in vaccinated HCWs. There was no statistically significant difference in the SARS-CoV-2 antibody results according to the occupations of the HCWs.

keywords:

healthcare worker, COVID-19, SARS-CoV-2, vaccine



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