Apoptosis and PTX3 in lichen planus

Ibrahim H. Yavuz; Göknur Özaydın Yavuz; Nazlı Caf; Mustafa Tümtürk; Harbiye Dilek Canat; Mehmet Onur Gökalp

doi:10.5114/ada.2024.145205

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

Apoptosis and PTX3 in lichen planus

Ibrahim H. Yavuz

¹

,

Göknur Özaydın Yavuz

²

,

Nazlı Caf

²

,

Mustafa Tümtürk

²

,

Harbiye Dilek Canat

²

,

Mehmet Onur Gökalp

¹

Department of Dermatology, Cam and Sakura City Hospital, Istanbul, Turkey
Department of Dermatology, Health Sciences University, Istanbul, Turkey

Adv Dermatol Allergol

DOI: https://doi.org/10.5114/ada.2024.145205

Online publish date: 2024/11/21

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Introduction:
Lichen planus (LP) is considered a T cell-mediated autoimmune disease although its aetiology remains unknown. Cytotoxic T cells play a central role in the pathogenesis of LP and these cells are known to significantly induce apoptosis in basal keratinocytes.

Aim:
To correlate pentraxin 3 (PTX3) with apoptosis in basal cell keratinocytes in LP and to determine whether it is a marker in this disease.

Material and methods:
Inclusion criteria were as follows: (i) providing written consent for participation, (ii) presence of typical clinical findings (livid-red, violaceous, flat-topped polygonal papules and plaques, fern appearance in the oral mucosa, flexural involvement, and Wickham’s striae) and (iii) histopathological confirmation of LP.

Results:
A total of 60 participants, 30 patients and 30 controls, were included in the study. No difference was found between groups in terms of age and gender. There was a significant difference in PTX3 levels between groups. As to patients with LP, 21 (70%) patients had skin involvement only, 2 (6.7%) patients had mucosal involvement only, and 7 (23.3%) patients had both skin and mucosal involvement of LP.

Conclusions:
PTX3 may be associated with apoptosis in LP. Although there are no data on the usability of PTX3 as a specific marker of LP, the present study aimed to demonstrate its usability as a marker of active LP.

keywords:

Apoptosis and PTX3 in lichen planus

Ibrahim H. Yavuz 1 , Göknur Özaydın Yavuz 2 , Nazlı Caf 2 , Mustafa Tümtürk 2 , Harbiye Dilek Canat 2 , Mehmet Onur Gökalp 1

lichen planus, pentraxin, apoptosis

Ibrahim H. Yavuz

¹

,

Göknur Özaydın Yavuz

²

,

Nazlı Caf

²

,

Mustafa Tümtürk

²

,

Harbiye Dilek Canat

²

,

Mehmet Onur Gökalp

¹