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eISSN: 2084-9893
ISSN: 0033-2526
Dermatology Review/Przegląd Dermatologiczny
Bieżący numer Archiwum Artykuły zaakceptowane O czasopiśmie Zeszyty specjalne Rada naukowa Bazy indeksacyjne Prenumerata Kontakt Zasady publikacji prac Standardy etyczne i procedury
Panel Redakcyjny
Zgłaszanie i recenzowanie prac online
SCImago Journal & Country Rank
3/2024
vol. 111
 
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Opis przypadku

Aseptic breast abscess syndrome as an example of neutrophilic dermatosis. Can an immune defect be the reason of a disease?

Przemysław Borowy
1, 2
,
Alicja Kamińska
3
,
Katarzyna Gołojuch
4
,
Urszula Chmielecka
5
,
Bogdan Batko
1, 2
,
Patrycja Sordoń
6
,
Ewa Chmielik
6

  1. Department of Rheumatology and Immunology, J. Dietl Hospital, Krakow, Poland
  2. Department of Rheumatology and Immunology, Andrzej Frycz-Modrzewski Kraków University, Poland
  3. Stefan Żeromski Specialist Hospital, Krakow, Poland
  4. Ludwik Rydygier Memorial Hospital, Krakow, Poland
  5. Regional Specialist Hospital in Wroclaw, Research and Development Center, Wroclaw, Poland
  6. Tumour Pathology Department, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland
Dermatol Rev/Przegl Dermatol 2024, 111, 234-237
Data publikacji online: 2024/11/08
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Metryki PlumX:


Introduction:
Aseptic abscess syndrome (AAS) is a rare neutrophilic dermatosis characterized by recurrent skin abscesses caused by the infiltration of neutrophils. The disease exhibits features of an autoimmune or autoinflammatory disorder with an unknown pathomechanism. The most effective therapeutic option is systemic use of glucocorticosteroids, and in severe cases, tumor necrosis factor-a inhibitors and anakinra.

Case report:
In our case, a 45-year-old woman was diagnosed with recurrent abscess-like lesions in the left breast. The differential diagnosis was expanded and included malignancy, mycobacteriosis, radiation sickness, and immunodeficiency, all of which were ruled out as potential pathomechanisms. No immune defect was identified to explain multinucleated cell activation.

Conclusions:
In this study, we conducted a comprehensive evaluation of the immune system, particularly neutrophils function, as there is limited literature on this subject. Although we could not identify an immune defect explaining the cell activation, glucocorticoid treatment proved effective and led to several months of remission.



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