Aseptic breast abscess syndrome as an example of neutrophilic dermatosis. Can an immune defect be the reason of a disease?

Przemysław Borowy; Alicja Kamińska; Katarzyna Gołojuch; Urszula Chmielecka; Bogdan Batko; Patrycja Sordoń; Ewa Chmielik

doi:10.5114/dr.2024.144655

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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3/2024
vol. 111

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abstract:

Case report

Aseptic breast abscess syndrome as an example of neutrophilic dermatosis. Can an immune defect be the reason of a disease?

Przemysław Borowy

^{1, 2}

,

Alicja Kamińska

³

,

Katarzyna Gołojuch

⁴

,

Urszula Chmielecka

⁵

,

Bogdan Batko

^{1, 2}

,

Patrycja Sordoń

⁶

,

Ewa Chmielik

⁶

Department of Rheumatology and Immunology, J. Dietl Hospital, Krakow, Poland
Department of Rheumatology and Immunology, Andrzej Frycz-Modrzewski Kraków University, Poland
Stefan Żeromski Specialist Hospital, Krakow, Poland
Ludwik Rydygier Memorial Hospital, Krakow, Poland
Regional Specialist Hospital in Wroclaw, Research and Development Center, Wroclaw, Poland
Tumour Pathology Department, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland

Dermatol Rev/Przegl Dermatol 2024, 111, 234-237

DOI: https://doi.org/10.5114/dr.2024.144655

Online publish date: 2024/11/08

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AMA

Borowy P, Kamińska A, Gołojuch K, et al. Aseptic breast abscess syndrome as an example of neutrophilic dermatosis. Can an immune defect be the reason of a disease?. Dermatology Review/Przegląd Dermatologiczny. 2024;111(3):234-237. doi:10.5114/dr.2024.144655.

APA

Borowy, P., Kamińska, A., Gołojuch, K., Chmielecka, U., Batko, B.,  & Sordoń, P. et al. (2024). Aseptic breast abscess syndrome as an example of neutrophilic dermatosis. Can an immune defect be the reason of a disease?. Dermatology Review/Przegląd Dermatologiczny, 111(3), 234-237. https://doi.org/10.5114/dr.2024.144655

Chicago

Borowy, Przemysław, Alicja Kamińska, Katarzyna Gołojuch, Urszula Chmielecka, Bogdan Batko, Patrycja Sordoń,  and Ewa Chmielik. 2024. "Aseptic breast abscess syndrome as an example of neutrophilic dermatosis. Can an immune defect be the reason of a disease?". Dermatology Review/Przegląd Dermatologiczny 111 (3): 234-237. doi:10.5114/dr.2024.144655.

Harvard

Borowy, P., Kamińska, A., Gołojuch, K., Chmielecka, U., Batko, B., Sordoń, P.,  and Chmielik, E. (2024). Aseptic breast abscess syndrome as an example of neutrophilic dermatosis. Can an immune defect be the reason of a disease?. Dermatology Review/Przegląd Dermatologiczny, 111(3), pp.234-237. https://doi.org/10.5114/dr.2024.144655

MLA

Borowy, Przemysław et al. "Aseptic breast abscess syndrome as an example of neutrophilic dermatosis. Can an immune defect be the reason of a disease?." Dermatology Review/Przegląd Dermatologiczny, vol. 111, no. 3, 2024, pp. 234-237. doi:10.5114/dr.2024.144655.

Vancouver

Borowy P, Kamińska A, Gołojuch K, Chmielecka U, Batko B, Sordoń P et al. Aseptic breast abscess syndrome as an example of neutrophilic dermatosis. Can an immune defect be the reason of a disease?. Dermatology Review/Przegląd Dermatologiczny. 2024;111(3):234-237. doi:10.5114/dr.2024.144655.

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Introduction:
Aseptic abscess syndrome (AAS) is a rare neutrophilic dermatosis characterized by recurrent skin abscesses caused by the infiltration of neutrophils. The disease exhibits features of an autoimmune or autoinflammatory disorder with an unknown pathomechanism. The most effective therapeutic option is systemic use of glucocorticosteroids, and in severe cases, tumor necrosis factor-a inhibitors and anakinra.

Case report:
In our case, a 45-year-old woman was diagnosed with recurrent abscess-like lesions in the left breast. The differential diagnosis was expanded and included malignancy, mycobacteriosis, radiation sickness, and immunodeficiency, all of which were ruled out as potential pathomechanisms. No immune defect was identified to explain multinucleated cell activation.

Conclusions:
In this study, we conducted a comprehensive evaluation of the immune system, particularly neutrophils function, as there is limited literature on this subject. Although we could not identify an immune defect explaining the cell activation, glucocorticoid treatment proved effective and led to several months of remission.

keywords:

Aseptic breast abscess syndrome as an example of neutrophilic dermatosis. Can an immune defect be the reason of a disease?

Przemysław Borowy 1, 2 , Alicja Kamińska 3 , Katarzyna Gołojuch 4 , Urszula Chmielecka 5 , Bogdan Batko 1, 2 , Patrycja Sordoń 6 , Ewa Chmielik 6

aseptic abscess, immunodeficiency, neutrophils, autoinflammatory disorder, glucocorticosteroids

Przemysław Borowy

^{1, 2}

,

Alicja Kamińska

³

,

Katarzyna Gołojuch

⁴

,

Urszula Chmielecka

⁵

,

Bogdan Batko

^{1, 2}

,

Patrycja Sordoń

⁶

,

Ewa Chmielik

⁶