Association of vitamin D receptor gene polymorphisms with risk of cutaneous melanoma. A meta-analysis based on 40 case-control studies

Seyed Mohammadreza Niktabar; Seyed Mojtaba Latifi; Mansour Moghimi; Jamal Jafari-Nedooshan; Kazem Aghili; Seyed Mohsen Miresmaeili; Masoud Zare-Shehneh; Hossein Neamatzadeh

doi:10.5114/dr.2019.86909

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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3/2019
vol. 106

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abstract:

Original article

Association of vitamin D receptor gene polymorphisms with risk of cutaneous melanoma. A meta-analysis based on 40 case-control studies

Seyed Mohammadreza Niktabar

¹

,

Seyed Mojtaba Latifi

¹

,

Mansour Moghimi

²

,

Jamal Jafari-Nedooshan

¹

,

Kazem Aghili

³

,

Seyed Mohsen Miresmaeili

⁴

,

Masoud Zare-Shehneh

⁵

,

Hossein Neamatzadeh

^{5, 6}

Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Department of Biology, Science and Arts University, Yazd, Iran
Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Dermatol Rev/Przegl Dermatol 2019, 106, 268–279

DOI: https://doi.org/10.5114/dr.2019.86909

Online publish date: 2019/08/24

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AMA

Niktabar S, Latifi S, Moghimi M, et al. Association of vitamin D receptor gene polymorphisms with risk of cutaneous melanoma. A meta-analysis based on 40 case-control studies. Dermatology Review/Przegląd Dermatologiczny. 2019;106(3):268-279. doi:10.5114/dr.2019.86909.

APA

Niktabar, S., Latifi, S., Moghimi, M., Jafari-Nedooshan, J., Aghili, K.,  & Mohsen Miresmaeili, S. et al. (2019). Association of vitamin D receptor gene polymorphisms with risk of cutaneous melanoma. A meta-analysis based on 40 case-control studies. Dermatology Review/Przegląd Dermatologiczny, 106(3), 268-279. https://doi.org/10.5114/dr.2019.86909

Chicago

Niktabar, Seyed Mohammadreza, Seyed Mojtaba Latifi, Mansour Moghimi, Jamal Jafari-Nedooshan, Kazem Aghili, Seyed Mohsen Miresmaeili,  and Masoud Zare-Shehneh et al. 2019. "Association of vitamin D receptor gene polymorphisms with risk of cutaneous melanoma. A meta-analysis based on 40 case-control studies". Dermatology Review/Przegląd Dermatologiczny 106 (3): 268-279. doi:10.5114/dr.2019.86909.

Harvard

Niktabar, S., Latifi, S., Moghimi, M., Jafari-Nedooshan, J., Aghili, K., Mohsen Miresmaeili, S., Zare-Shehneh, M.,  and Neamatzadeh, H. (2019). Association of vitamin D receptor gene polymorphisms with risk of cutaneous melanoma. A meta-analysis based on 40 case-control studies. Dermatology Review/Przegląd Dermatologiczny, 106(3), pp.268-279. https://doi.org/10.5114/dr.2019.86909

MLA

Niktabar, Seyed Mohammadreza et al. "Association of vitamin D receptor gene polymorphisms with risk of cutaneous melanoma. A meta-analysis based on 40 case-control studies." Dermatology Review/Przegląd Dermatologiczny, vol. 106, no. 3, 2019, pp. 268-279. doi:10.5114/dr.2019.86909.

Vancouver

Niktabar S, Latifi S, Moghimi M, Jafari-Nedooshan J, Aghili K, Mohsen Miresmaeili S et al. Association of vitamin D receptor gene polymorphisms with risk of cutaneous melanoma. A meta-analysis based on 40 case-control studies. Dermatology Review/Przegląd Dermatologiczny. 2019;106(3):268-279. doi:10.5114/dr.2019.86909.

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Introduction
Previous studies on the association of vitamin D receptor (VDR) gene polymorphisms with cutaneous melanoma risk reported conflicting results.

Objective
To obtain a more precise assessment of the associations, we performed a meta-analysis of previously published studies.

Material and methods
We searched for eligible studies in the PubMed, Embase, and CNKI databases. A total of 40 case-control studies with 1,144 cases and 2,925 controls were included.

Results
The pooled analyses suggested a significant association between the FokI C>T and BsmI G>A polymorphisms of the VDR gene and susceptibility to melanoma. However, we found that the VDR TaqI T>C, EcoRV A>G, ApaI G>T, and Cdx2 G>A polymorphisms were not associated with melanoma risk.

Conclusions
The meta-analysis suggests that VDR FokI C>T and BsmI G>A polymorphisms are significantly associated with melanoma risk, while TaqI T>C, EcoRV A>G, ApaI G>T, and Cdx2 G>A polymorphisms are not associated with melanoma risk.

keywords:

Association of vitamin D receptor gene polymorphisms with risk of cutaneous melanoma. A meta-analysis based on 40 case-control studies

Seyed Mohammadreza Niktabar 1 , Seyed Mojtaba Latifi 1 , Mansour Moghimi 2 , Jamal Jafari-Nedooshan 1 , Kazem Aghili 3 , Seyed Mohsen Miresmaeili 4 , Masoud Zare-Shehneh 5 , Hossein Neamatzadeh 5, 6

cutaneous melanoma, vitamin D receptor, polymorphism, meta-analysis

Seyed Mohammadreza Niktabar

¹

,

Seyed Mojtaba Latifi

¹

,

Mansour Moghimi

²

,

Jamal Jafari-Nedooshan

¹

,

Kazem Aghili

³

,

Seyed Mohsen Miresmaeili

⁴

,

Masoud Zare-Shehneh

⁵

,

Hossein Neamatzadeh

^{5, 6}