Autologous stem cell transplantation (ASCT) as a consolidation  of remission in peripheral T-cell lymphoma (PTCL) – the preliminary results of the first 11 patients

Beata Stella-Hołowiecka; Agata Wieczorkiewicz; Grzegorz Helbig; Grażyna Bober; Maria Wojciechowska; Jacek Najda; Lucja Kachel; Jerzy Hołowiecki

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ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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7/2007
vol. 11

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abstract:

Autologous stem cell transplantation (ASCT) as a consolidation of remission in peripheral T-cell lymphoma (PTCL) – the preliminary results of the first 11 patients

Beata Stella-Hołowiecka

,

Agata Wieczorkiewicz

,

Grzegorz Helbig

,

Grażyna Bober

,

Maria Wojciechowska

,

Jacek Najda

,

Lucja Kachel

,

Jerzy Hołowiecki

Współczesna Onkologia (2007) vol. 11; 7 (376–380)

Online publish date: 2007/10/02

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AMA

Stella-Hołowiecka B, Wieczorkiewicz A, Helbig G, et al. Autologous stem cell transplantation (ASCT) as a consolidation  of remission in peripheral T-cell lymphoma (PTCL) – the preliminary results of the first 11 patients. Contemporary Oncology/Współczesna Onkologia. 2007;11(7):376-380.

APA

Stella-Hołowiecka, B., Wieczorkiewicz, A., Helbig, G., Bober, G., Wojciechowska, M.,  & Najda, J. et al. (2007). Autologous stem cell transplantation (ASCT) as a consolidation  of remission in peripheral T-cell lymphoma (PTCL) – the preliminary results of the first 11 patients. Contemporary Oncology/Współczesna Onkologia, 11(7), 376-380.

Chicago

Stella-Hołowiecka, Beata, Agata Wieczorkiewicz, Grzegorz Helbig, Grażyna Bober, Maria Wojciechowska, Jacek Najda,  and Lucja Kachel et al. 2007. "Autologous stem cell transplantation (ASCT) as a consolidation  of remission in peripheral T-cell lymphoma (PTCL) – the preliminary results of the first 11 patients". Contemporary Oncology/Współczesna Onkologia 11 (7): 376-380.

Harvard

Stella-Hołowiecka, B., Wieczorkiewicz, A., Helbig, G., Bober, G., Wojciechowska, M., Najda, J., Kachel, L.,  and Hołowiecki, J. (2007). Autologous stem cell transplantation (ASCT) as a consolidation  of remission in peripheral T-cell lymphoma (PTCL) – the preliminary results of the first 11 patients. Contemporary Oncology/Współczesna Onkologia, 11(7), pp.376-380.

MLA

Stella-Hołowiecka, Beata et al. "Autologous stem cell transplantation (ASCT) as a consolidation  of remission in peripheral T-cell lymphoma (PTCL) – the preliminary results of the first 11 patients." Contemporary Oncology/Współczesna Onkologia, vol. 11, no. 7, 2007, pp. 376-380.

Vancouver

Stella-Hołowiecka B, Wieczorkiewicz A, Helbig G, Bober G, Wojciechowska M, Najda J et al. Autologous stem cell transplantation (ASCT) as a consolidation  of remission in peripheral T-cell lymphoma (PTCL) – the preliminary results of the first 11 patients. Contemporary Oncology/Współczesna Onkologia. 2007;11(7):376-380.

Background: Peripheral T-cell lymphomas show aggressive course and poor outcome. High-dose chemotherapy is thought to improve outcome in these patients, but the role of up-front ASCT is still unclear. Material and methods: 11 patients (5 male/6 female); median age at ASCT was 41 years. The CHOP regimen was administered as an induction treatment. The median number of chemotherapy regimens needed to achieve CR or PR was 8 (range 3-20). 7 patients (64%) achieved complete remission before ASCT; 4 showed PR. The conditioning regimen was CBV for 10 patients and 1 patient received BEAM. Results: The median number of mononuclear cells was 3.5 × 108/kg (range 2.02-6.9); median CD34+ cell dose infused/kg was 6.2 × 106/kg (range 1.1-17.2). Engraftment of neutrophils >0.5 × 109/l was observed at a median of 14 days (range 12-18), engraftment of platelets >50 × 109/l was achieved in a median of 16 (range 10-30). The 100-day mortality rate was 0%. 4 out of 11 patients (36%) developed progression/relapse after ASCT after a median of 7 months (range 4-9). 3 out of 4 patients died in disease progression, 1 patient underwent allogeneic stem cell transplantation. Only 1 out of 7 patients transplanted in CR had an early relapse occurring 4 months after ASCT. With a median of 20 months (range 6-52) of follow-up 6 patients (55%) remain in CR. The estimated probability of 3-year overall survival (OS) and progression-free survival (PFS) is 60% and 62% respectively. Conclusions: Up-front ASCT in PTCL is highly effective, but further study with a large post-transplant population are needed to confirm the results.

keywords:

Autologous stem cell transplantation (ASCT) as a consolidation of remission in peripheral T-cell lymphoma (PTCL) – the preliminary results of the first 11 patients

Beata Stella-Hołowiecka , Agata Wieczorkiewicz , Grzegorz Helbig , Grażyna Bober , Maria Wojciechowska , Jacek Najda , Lucja Kachel , Jerzy Hołowiecki

peripheral T-cell lymphoma, consolidation of remission, autologous stem cell transplantation

Beata Stella-Hołowiecka

,

Agata Wieczorkiewicz

,

Grzegorz Helbig

,

Grażyna Bober

,

Maria Wojciechowska

,

Jacek Najda

,

Lucja Kachel

,

Jerzy Hołowiecki