Biochemical aspects of modified, transdermal replacement hormone therapy

Objective:
an evaluation of the influence of modified transdermal hormone replacement therapy (HRT) and hormone supplement therapy (HST) on concentration of follicle-stimulating hormone (FSH), lutein hormone (LH), estrone (E1), estradiol (E2), PR, IGF-1, GH and bone density of lumbar vertebrae in women with osteopenia in the postmenopausal period.

Material and methods:
65 women were enrolled, aged 43-58, divided into three groups based on a randomized list. Group I used intracutaneous placebo, group II used intracutaneous hormonal therapy (HRT) and group III used hormonal therapy per os (HST).
The concentrations of hormones were estimated by radioimmunoenzymatic methods. Statistical analysis was performed based on Statistical PL.

Result:
after intracutaneous hormonal therapy (HRT) the concentrations of hormones are normalized and there is increased bone density of lumbar vertebrae. Hormonal therapy per os (HST).

Conclusions:
1. Transdermal hormone replacement therapy (HRT) modulates concentration of sex hormones and bone metabolism.
2. Hyperoestrogenism, hyperprolactinaemia, decreased IGF-1 concentration and low mineral density in women after HST could cause disorders of chemical oestrogen metabolism.