Blood-brain barrier ultrastructural alterations in human congenital hydrocephalus and Arnold-Chiari malformation

Orlando J. Castejón

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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1/2009
vol. 47

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abstract:

Blood-brain barrier ultrastructural alterations in human congenital hydrocephalus and Arnold-Chiari malformation

Orlando J. Castejón

Folia Neuropathol 2009; 47 (1): 11-19

Online publish date: 2009/03/26

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Cortical biopsies of 13 patients with clinical diagnosis of congenital hydrocephalus, Arnold-Chiari malformation and hydrocephalus, and postmeningitis hydrocephalus were examined by transmission electron microscopy to study the damage of endothelial cells, basement membrane, astrocytic end-feet layer, and perivascular space. Capillaries from the parietal and frontal cortex showed increased vesicular and vacuolar transport, intact endothelial junctions, thin and immature basement membrane, swollen perivascular astrocytic end-feet layer, and enlarged perivascular space. In areas of severe oedema, open endothelial junctions, swollen basement membrane, absent perivascular astrocytic end-feet layer, enlarged perivascular space, and disrupted perivascular neuropil were observed. The electron microscopic findings demonstrated breakdown of the blood-brain barrier in all cases examined.

keywords:

Blood-brain barrier ultrastructural alterations in human congenital hydrocephalus and Arnold-Chiari malformation

Orlando J. Castejón

blood-brain barrier, congenital hydrocephalus, Arnold-Chiari malformation, electron microscopy