eISSN: 2081-2841
ISSN: 1689-832X
Journal of Contemporary Brachytherapy
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1/2024
vol. 16
 
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abstract:
Original paper

Brachytherapy in gynecological malignancies at a tertiary care hospital: An analysis

Rasla Parween
1
,
Aruna R
1
,
Chendil V
1
,
Mahita Reddy
1
,
Ramyaa S
1
,
Varun Chandra
1
,
Yuvaraj U
1
,
Amrut S Kadam
1

  1. Department of Radiation Oncology, Victoria Hospital, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India
J Contemp Brachytherapy 2024; 16, 1: 67–71
DOI: https://doi.org/10.5114/jcb.2024.135628
Online publish date: 2024/02/27
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Purpose:
Brachytherapy plays a crucial role in the standard of care for locally advanced gynecological malignancies. In this report, we present the experience from a tertiary teaching hospital, which is a referral center for image-guided brachytherapy (IGBT) in the management of locally advanced gynecological malignancies.

Material and methods:
This was a retrospective study of 130 patients referred to our hospital for IGBT after receiving initial external beam radiotherapy in their primary healthcare facilities, from January 2021 till January 2023. CT-based planning was done to delineate high-risk clinical target volume (HR-CTV). Dose of 6-7.5 Gy in 3-4 fractions was prescribed. Overall treatment time (OTT) was calculated, and patients were assessed for clinical response and toxicity after three months.

Results:
All patients received IGBT using an intra-cavitary or interstitial technique. The D90 HR-CTV mean EQD2 dose was 28.34 ±2.78 Gy. The mean EQD2 dose to 2 cc of the bladder, rectum, and sigmoid was 18.31 ±5.19 Gy, 14.14 ±5.76 Gy, and 17.43 ±4.75 Gy, respectively. The median interval time between the last fraction of external beam radiation therapy (EBRT) and first evaluation in the hospital was 19 (range, 13-28) days (interquartile range [IQR]). The median time between the completion of chemoradiation and brachytherapy procedure was 25 (range, 19-33) days (IQR). The mean overall treatment time (OTT) was 63.5 ±14.7 days.

Conclusions:
This study highlights the established advantages of image-guided interstitial brachytherapy and associated challenges. To optimize the overall treatment duration, it is imperative to prioritize and update the referral processes for brachytherapy centers.

keywords:

brachytherapy, ISBT, HDR, gynecological cancer

  
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