Brachytherapy or enucleation in ring melanoma patients: which is better? Preliminary results of the authors’ own experiences

Anna Markiewicz; Karolina Gerba-Górecka; Barbara Jakubowska; Magdalena Dębicka-Kumela; Joanna Kowal; Izabella Karska-Basta; Konrad Skórkiewicz; Bożena Romanowska-Dixon

doi:10.5114/jcb.2021.108598

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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abstract:

Original paper

Brachytherapy or enucleation in ring melanoma patients: which is better? Preliminary results of the authors’ own experiences

Anna Markiewicz

^{1, 2}

,

Karolina Gerba-Górecka

,

Barbara Jakubowska

²

,

Magdalena Dębicka-Kumela

^{1, 2}

,

Joanna Kowal

^{1, 2}

,

Izabella Karska-Basta

^{1, 2}

,

Konrad Skórkiewicz

^{2, 3}

,

Bożena Romanowska-Dixon

^{1, 2}

Department of Ophthalmology and Ocular Oncology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland
Department of Ophthalmology and Ocular Oncology, University Hospital, Krakow, Poland
Jagiellonian University, Faculty of Physics, Astronomy and Applied Computer Science, Krakow, Poland

J Contemp Brachytherapy 2021; 13, 4: 433–440

DOI: https://doi.org/10.5114/jcb.2021.108598

Online publish date: 2021/08/24

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AMA

Markiewicz A, Gerba-Górecka K, Jakubowska B, et al. Brachytherapy or enucleation in ring melanoma patients: which is better? Preliminary results of the authors’ own experiences. Journal of Contemporary Brachytherapy. 2021;13(4):433-440. doi:10.5114/jcb.2021.108598.

APA

Markiewicz, A., Gerba-Górecka, K., Jakubowska, B., Dębicka-Kumela, M., Kowal, J.,  & Karska-Basta, I. et al. (2021). Brachytherapy or enucleation in ring melanoma patients: which is better? Preliminary results of the authors’ own experiences. Journal of Contemporary Brachytherapy, 13(4), 433-440. https://doi.org/10.5114/jcb.2021.108598

Chicago

Markiewicz, Anna, Karolina Gerba-Górecka, Barbara Jakubowska, Magdalena Dębicka-Kumela, Joanna Kowal, Izabella Karska-Basta,  and Konrad Skórkiewicz et al. 2021. "Brachytherapy or enucleation in ring melanoma patients: which is better? Preliminary results of the authors’ own experiences". Journal of Contemporary Brachytherapy 13 (4): 433-440. doi:10.5114/jcb.2021.108598.

Harvard

Markiewicz, A., Gerba-Górecka, K., Jakubowska, B., Dębicka-Kumela, M., Kowal, J., Karska-Basta, I., Skórkiewicz, K.,  and Romanowska-Dixon, B. (2021). Brachytherapy or enucleation in ring melanoma patients: which is better? Preliminary results of the authors’ own experiences. Journal of Contemporary Brachytherapy, 13(4), pp.433-440. https://doi.org/10.5114/jcb.2021.108598

MLA

Markiewicz, Anna et al. "Brachytherapy or enucleation in ring melanoma patients: which is better? Preliminary results of the authors’ own experiences." Journal of Contemporary Brachytherapy, vol. 13, no. 4, 2021, pp. 433-440. doi:10.5114/jcb.2021.108598.

Vancouver

Markiewicz A, Gerba-Górecka K, Jakubowska B, Dębicka-Kumela M, Kowal J, Karska-Basta I et al. Brachytherapy or enucleation in ring melanoma patients: which is better? Preliminary results of the authors’ own experiences. Journal of Contemporary Brachytherapy. 2021;13(4):433-440. doi:10.5114/jcb.2021.108598.

Introduction
A retrospective evaluation of effectiveness of brachytherapy or enucleation in treatment of rare form of uveal melanoma: ring melanoma.

Material and methods
Analysis comprised 49 patients treated from 2000 to 2019 for ring melanoma involving ciliary body. In 15 patients, primary treatment consisted of brachytherapy (106Ru or 125I), whereas in 34 patients, eyeballs were enucleated. The evaluation concerned differences between analyzed groups relating to the clinical and histopathological features as well as overall survival, cancer-specific overall survival, and disease-free survival.

Results
No significant differences between the analyzed groups were found with regards to clinical and histopathological features, apart from intra-ocular pressure (increased in the enucleation group). Kaplan-Meier analysis did not reveal any significant differences between the group treated with enucleation and the group undergoing brachytherapy, both with regards to overall survival (p = 0.325) and cancer-specific overall survival (p = 0.477). A significant difference was observed in disease-free survival (p = 0.009), which was significantly shorter in the group undergoing brachytherapy. In the analysis of parameters of the applied brachytherapy, no significant differences between patients with and without local recurrence were found. Mean observation period was 350.8 weeks (range, 24-996 weeks, SD = 231.6). A local recurrence occurred in 11 (22.4%) patients, including 3 (6.1%) in enucleation and 8 (16.3%) after brachytherapy groups. Metastasis developed in 11 (22.4%) cases after a mean follow-up of 133 weeks (33.25 months), range 3-655 weeks.

Conclusions
Preliminary observations may suggest that brachytherapy in this rare form of uveal melanoma, such as ring melanoma involving the ciliary body, may be taken into consideration as a useful alternative to enucleation. However, the confirmation of such an approach requires a larger patients’ group to be gathered, and also a longer follow-up period. This is especially important in patients with a good baseline visual acuity in the affected eye, or when the neoplasm is present in the remaining eye with vision.

keywords:

Brachytherapy or enucleation in ring melanoma patients: which is better? Preliminary results of the authors’ own experiences

Anna Markiewicz 1, 2 , Karolina Gerba-Górecka , Barbara Jakubowska 2 , Magdalena Dębicka-Kumela 1, 2 , Joanna Kowal 1, 2 , Izabella Karska-Basta 1, 2 , Konrad Skórkiewicz 2, 3 , Bożena Romanowska-Dixon 1, 2

ring melanoma, brachytherapy, enucleation, ocular melanoma, uveal melanoma, melanoma

Anna Markiewicz

^{1, 2}

,

Karolina Gerba-Górecka

,

Barbara Jakubowska

²

,

Magdalena Dębicka-Kumela

^{1, 2}

,

Joanna Kowal

^{1, 2}

,

Izabella Karska-Basta

^{1, 2}

,

Konrad Skórkiewicz

^{2, 3}

,

Bożena Romanowska-Dixon

^{1, 2}